Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production.

Published

Journal Article

Nitric oxide (NO) production and mononuclear cell NO synthase 2 (NOS2) expression are high in healthy Tanzanian children but low in those with cerebral malaria. Factors that downregulate NOS2 also diminish factors involved in cellular uptake and biosynthesis of L-arginine, the substrate for NO synthesis. We therefore postulated that L-arginine concentrations would be low in individuals with cerebral malaria. We measured concentrations of L-arginine in cryopreserved plasma samples from Tanzanian children with and without malaria. L-arginine concentrations were low in individuals with cerebral malaria (mean 46 micromol/L, SD 14), intermediate in those with uncomplicated malaria (70 micromol/L, 20), and within the normal range in healthy controls (122 micromol/L, 22; p<0.0001). Analysis by logistic regression showed that hypoargininaemia was significantly associated with cerebral malaria case-fatality. Hypoargininaemia may contribute to limited NO production in children with cerebral malaria and to severe disease.

Full Text

Duke Authors

Cited Authors

  • Lopansri, BK; Anstey, NM; Weinberg, JB; Stoddard, GJ; Hobbs, MR; Levesque, MC; Mwaikambo, ED; Granger, DL

Published Date

  • February 22, 2003

Published In

Volume / Issue

  • 361 / 9358

Start / End Page

  • 676 - 678

PubMed ID

  • 12606182

Pubmed Central ID

  • 12606182

International Standard Serial Number (ISSN)

  • 0140-6736

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(03)12564-0

Language

  • eng

Conference Location

  • England