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Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells.

Publication ,  Journal Article
Shami, PJ; Moore, JO; Gockerman, JP; Hathorn, JW; Misukonis, MA; Weinberg, JB
Published in: Leuk Res
August 1995

Freshly isolated acute non-lymphocytic leukemia (ANLL) cells were treated with the nitric oxide (NO)-liberating compounds sodium nitroprusside or S-nitrosoacetyl penicillamine and analyzed for viability, growth, and differentiation at 3-5 days. NO decreased the viability and the growth of freshly isolated ANLL cells in vitro. NO treatment significantly increased expression of CD14 in blast cells from patients with M5 ANLL, and increased at least one differentiation parameter in M4 or M5 cells. It had little or no effect on parameters of differentiation in other ANLL cells. We conclude that in vitro culture with NO decreases the growth and viability of most freshly isolated ANLL cells. NO also induces the differentiation of ANLL cells with a monocytic phenotype.

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Published In

Leuk Res

DOI

ISSN

0145-2126

Publication Date

August 1995

Volume

19

Issue

8

Start / End Page

527 / 533

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • S-Nitroso-N-Acetylpenicillamine
  • Penicillamine
  • Nitroprusside
  • Nitric Oxide
  • Leukemia, Myeloid, Acute
  • Immunology
  • Humans
  • Cell Survival
  • Cell Division
 

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Shami, P. J., Moore, J. O., Gockerman, J. P., Hathorn, J. W., Misukonis, M. A., & Weinberg, J. B. (1995). Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells. Leuk Res, 19(8), 527–533. https://doi.org/10.1016/0145-2126(95)00013-e
Shami, P. J., J. O. Moore, J. P. Gockerman, J. W. Hathorn, M. A. Misukonis, and J. B. Weinberg. “Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells.Leuk Res 19, no. 8 (August 1995): 527–33. https://doi.org/10.1016/0145-2126(95)00013-e.
Shami PJ, Moore JO, Gockerman JP, Hathorn JW, Misukonis MA, Weinberg JB. Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells. Leuk Res. 1995 Aug;19(8):527–33.
Shami, P. J., et al. “Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells.Leuk Res, vol. 19, no. 8, Aug. 1995, pp. 527–33. Pubmed, doi:10.1016/0145-2126(95)00013-e.
Shami PJ, Moore JO, Gockerman JP, Hathorn JW, Misukonis MA, Weinberg JB. Nitric oxide modulation of the growth and differentiation of freshly isolated acute non-lymphocytic leukemia cells. Leuk Res. 1995 Aug;19(8):527–533.
Journal cover image

Published In

Leuk Res

DOI

ISSN

0145-2126

Publication Date

August 1995

Volume

19

Issue

8

Start / End Page

527 / 533

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • S-Nitroso-N-Acetylpenicillamine
  • Penicillamine
  • Nitroprusside
  • Nitric Oxide
  • Leukemia, Myeloid, Acute
  • Immunology
  • Humans
  • Cell Survival
  • Cell Division