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Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria.

Publication ,  Journal Article
Kun, JF; Mordmüller, B; Perkins, DJ; May, J; Mercereau-Puijalon, O; Alpers, M; Weinberg, JB; Kremsner, PG
Published in: J Infect Dis
August 1, 2001

A point mutation in the promoter of the nitric oxide synthase 2 gene (NOS2), termed NOS2(Lambaréné) (NOS2-G954C), protects heterozygous carriers against severe malaria as effectively as the sickle cell trait. In a prospective longitudinal study, 841 individual infections of initially 200 children (151 wild-type vs. 49 NOS2(Lambaréné) carriers) were monitored for 4 years, to assess the rates of malarial attacks in the 2 groups; carriers of the NOS2(Lambaréné) polymorphism were significantly less likely to experience malarial attacks than were others (P=.002). The distribution of the NOS2(Lambaréné) polymorphism was investigated in malaria-endemic areas. It was found to be present with the highest frequency in Africa and at a lower frequency in Asia. Ex vivo studies showed that cells isolated from people with this polymorphism have a 7-fold higher baseline NOS activity, compared with the levels detected in cells from subjects with the wild-type gene (P=.003).

Duke Scholars

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

August 1, 2001

Volume

184

Issue

3

Start / End Page

330 / 336

Location

United States

Related Subject Headings

  • Thailand
  • Senegal
  • Polymorphism, Single Nucleotide
  • Polymerase Chain Reaction
  • Point Mutation
  • Papua New Guinea
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Nigeria
 

Citation

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Kun, J. F., Mordmüller, B., Perkins, D. J., May, J., Mercereau-Puijalon, O., Alpers, M., … Kremsner, P. G. (2001). Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria. J Infect Dis, 184(3), 330–336. https://doi.org/10.1086/322037
Kun, J. F., B. Mordmüller, D. J. Perkins, J. May, O. Mercereau-Puijalon, M. Alpers, J. B. Weinberg, and P. G. Kremsner. “Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria.J Infect Dis 184, no. 3 (August 1, 2001): 330–36. https://doi.org/10.1086/322037.
Kun JF, Mordmüller B, Perkins DJ, May J, Mercereau-Puijalon O, Alpers M, et al. Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria. J Infect Dis. 2001 Aug 1;184(3):330–6.
Kun, J. F., et al. “Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria.J Infect Dis, vol. 184, no. 3, Aug. 2001, pp. 330–36. Pubmed, doi:10.1086/322037.
Kun JF, Mordmüller B, Perkins DJ, May J, Mercereau-Puijalon O, Alpers M, Weinberg JB, Kremsner PG. Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria. J Infect Dis. 2001 Aug 1;184(3):330–336.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

August 1, 2001

Volume

184

Issue

3

Start / End Page

330 / 336

Location

United States

Related Subject Headings

  • Thailand
  • Senegal
  • Polymorphism, Single Nucleotide
  • Polymerase Chain Reaction
  • Point Mutation
  • Papua New Guinea
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase
  • Nitric Oxide
  • Nigeria