Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria.


Journal Article

A point mutation in the promoter of the nitric oxide synthase 2 gene (NOS2), termed NOS2(Lambaréné) (NOS2-G954C), protects heterozygous carriers against severe malaria as effectively as the sickle cell trait. In a prospective longitudinal study, 841 individual infections of initially 200 children (151 wild-type vs. 49 NOS2(Lambaréné) carriers) were monitored for 4 years, to assess the rates of malarial attacks in the 2 groups; carriers of the NOS2(Lambaréné) polymorphism were significantly less likely to experience malarial attacks than were others (P=.002). The distribution of the NOS2(Lambaréné) polymorphism was investigated in malaria-endemic areas. It was found to be present with the highest frequency in Africa and at a lower frequency in Asia. Ex vivo studies showed that cells isolated from people with this polymorphism have a 7-fold higher baseline NOS activity, compared with the levels detected in cells from subjects with the wild-type gene (P=.003).

Full Text

Duke Authors

Cited Authors

  • Kun, JF; Mordmüller, B; Perkins, DJ; May, J; Mercereau-Puijalon, O; Alpers, M; Weinberg, JB; Kremsner, PG

Published Date

  • August 1, 2001

Published In

Volume / Issue

  • 184 / 3

Start / End Page

  • 330 - 336

PubMed ID

  • 11443559

Pubmed Central ID

  • 11443559

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/322037


  • eng

Conference Location

  • United States