Macrophage tumor killing: influence of the local environment.
Publication
, Journal Article
Hibbs, JB; Taintor, RR; Chapman, HA; Weinberg, JB
Published in: Science
July 15, 1977
Tumor killing by activated macrophages is not a highly determined biologic event, but a relative capability influenced by the local environment. An intrinsic macrophage cytotoxic effector system is modulated by serum and other environmental factors that can either enhance or suppress tumor killing. Activated macrophages kill tumor cells only when a regulating threshold drops to a critically low level.
Duke Scholars
Published In
Science
DOI
ISSN
0036-8075
Publication Date
July 15, 1977
Volume
197
Issue
4300
Start / End Page
279 / 282
Location
United States
Related Subject Headings
- Trypsin
- Toxoplasma
- Neoplasms, Experimental
- Mycobacterium bovis
- Macrophages
- Lymphokines
- General Science & Technology
- Enzyme Inhibitors
- Endotoxins
- Culture Media
Citation
APA
Chicago
ICMJE
MLA
NLM
Hibbs, J. B., Taintor, R. R., Chapman, H. A., & Weinberg, J. B. (1977). Macrophage tumor killing: influence of the local environment. Science, 197(4300), 279–282. https://doi.org/10.1126/science.327547
Hibbs, J. B., R. R. Taintor, H. A. Chapman, and J. B. Weinberg. “Macrophage tumor killing: influence of the local environment.” Science 197, no. 4300 (July 15, 1977): 279–82. https://doi.org/10.1126/science.327547.
Hibbs JB, Taintor RR, Chapman HA, Weinberg JB. Macrophage tumor killing: influence of the local environment. Science. 1977 Jul 15;197(4300):279–82.
Hibbs, J. B., et al. “Macrophage tumor killing: influence of the local environment.” Science, vol. 197, no. 4300, July 1977, pp. 279–82. Pubmed, doi:10.1126/science.327547.
Hibbs JB, Taintor RR, Chapman HA, Weinberg JB. Macrophage tumor killing: influence of the local environment. Science. 1977 Jul 15;197(4300):279–282.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
July 15, 1977
Volume
197
Issue
4300
Start / End Page
279 / 282
Location
United States
Related Subject Headings
- Trypsin
- Toxoplasma
- Neoplasms, Experimental
- Mycobacterium bovis
- Macrophages
- Lymphokines
- General Science & Technology
- Enzyme Inhibitors
- Endotoxins
- Culture Media