Macrophage tumor killing: influence of the local environment.

Journal Article (Journal Article)

Tumor killing by activated macrophages is not a highly determined biologic event, but a relative capability influenced by the local environment. An intrinsic macrophage cytotoxic effector system is modulated by serum and other environmental factors that can either enhance or suppress tumor killing. Activated macrophages kill tumor cells only when a regulating threshold drops to a critically low level.

Full Text

Duke Authors

Cited Authors

  • Hibbs, JB; Taintor, RR; Chapman, HA; Weinberg, JB

Published Date

  • July 15, 1977

Published In

Volume / Issue

  • 197 / 4300

Start / End Page

  • 279 - 282

PubMed ID

  • 327547

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.327547


  • eng

Conference Location

  • United States