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Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans.

Publication ,  Journal Article
Oates, JC; Levesque, MC; Hobbs, MR; Smith, EG; Molano, ID; Page, GP; Hill, BS; Weinberg, JB; Cooper, GS; Gilkeson, GS
Published in: J Rheumatol
January 2003

OBJECTIVE: Systemic lupus erythematosus (SLE) is an autoimmune disease in which morbidity and mortality are higher in African-Americans. The etiology of this racial disparity is unknown. A genetic predisposition to enhanced nitric oxide (NO) production may predispose African-Americans to develop SLE and may increase disease severity. We have demonstrated a correlation between NO production and disease activity in SLE. Two polymorphisms in the inducible NO synthase (NOS2) promoter region (G-954C and CCTTT microsatellite repeat polymorphisms) are associated with improved outcome in some African patients with malaria. This study was designed to determine if these polymorphisms are associated with SLE. METHODS: We assessed the frequency of both the G-954C and CCTTT microsatellite repeat NOS2 promoter polymorphisms in a cohort of patients with SLE and age, sex, and race matched controls in North Carolina and South Carolina. RESULTS: Both polymorphisms were more frequent among African-American female SLE patients when compared with controls (p = 0.04 for the G-954C polymorphism and p = 0.03 for the CCTTT-8 repeat polymorphism). Further, the G-954C and CCTTT-8 repeat polymorphisms were in linkage disequilibrium (D cent = 0.89, p = 0.0001) among African-American female SLE patients. CONCLUSION: Altered genetic control of NOS2 transcription may be a risk factor for SLE among African-American females. The extent of linkage disequilibrium between the G-954C and CCTTT-8 repeat NOS2 promoter polymorphisms suggests that they were co-inherited.

Duke Scholars

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

January 2003

Volume

30

Issue

1

Start / End Page

60 / 67

Location

Canada

Related Subject Headings

  • White People
  • Tyrosine
  • Sex Distribution
  • Risk Factors
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase
  • Microsatellite Repeats
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Oates, J. C., Levesque, M. C., Hobbs, M. R., Smith, E. G., Molano, I. D., Page, G. P., … Gilkeson, G. S. (2003). Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans. J Rheumatol, 30(1), 60–67.
Oates, Jim C., Marc C. Levesque, Maurine R. Hobbs, Erica Grace Smith, Ivan D. Molano, Grier P. Page, Bruce S. Hill, J Brice Weinberg, Glinda S. Cooper, and Gary S. Gilkeson. “Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans.J Rheumatol 30, no. 1 (January 2003): 60–67.
Oates JC, Levesque MC, Hobbs MR, Smith EG, Molano ID, Page GP, et al. Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans. J Rheumatol. 2003 Jan;30(1):60–7.
Oates, Jim C., et al. “Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans.J Rheumatol, vol. 30, no. 1, Jan. 2003, pp. 60–67.
Oates JC, Levesque MC, Hobbs MR, Smith EG, Molano ID, Page GP, Hill BS, Weinberg JB, Cooper GS, Gilkeson GS. Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans. J Rheumatol. 2003 Jan;30(1):60–67.

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

January 2003

Volume

30

Issue

1

Start / End Page

60 / 67

Location

Canada

Related Subject Headings

  • White People
  • Tyrosine
  • Sex Distribution
  • Risk Factors
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase
  • Microsatellite Repeats
  • Male