Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels.


Journal Article

B cell chronic lymphocytic leukemia (CLL) CD38 expression is variable and may predict outcome. Inducible nitric oxide synthase (NOS2) expression regulates CLL cell apoptosis. IL-4 and IFN-gamma regulate B cell CD38 expression and NOS2 expression. We compared IL-4 and IFN-gamma serum levels between CLL patients and normal individuals, and determined whether serum IL-4 and IFN-gamma levels correlated with CLL cell CD38 expression and NOS enzyme activity. IL-4 levels, but not IFN-gamma levels, differed between normal individuals and CLL patients. Furthermore, there was an association of IL-4 levels, but not IFN-gamma levels, with CD38 and NOS2 expression in CLL patients.

Full Text

Duke Authors

Cited Authors

  • Levesque, MC; Chen, Y; Beasley, BE; O'Loughlin, CW; Gockerman, JP; Moore, JO; Weinberg, JB

Published Date

  • January 2006

Published In

Volume / Issue

  • 30 / 1

Start / End Page

  • 24 - 28

PubMed ID

  • 16039714

Pubmed Central ID

  • 16039714

International Standard Serial Number (ISSN)

  • 0145-2126

Digital Object Identifier (DOI)

  • 10.1016/j.leukres.2005.05.022


  • eng

Conference Location

  • England