Interleukin-1 and tumor necrosis factor alpha inhibit repair of the porcine meniscus in vitro.

In Vitro, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.

Injury or removal of the knee meniscus leads to progressive joint degeneration, and current surgical therapies for meniscal tears seek to maximally preserve meniscal structure and function. However, the factors that influence intrinsic repair of the meniscus are not well understood. The goal of this study was to investigate the capacity of meniscus tissue to repair a simulated defect in vitro and to examine the effect of pro-inflammatory cytokines on this process.

Full Text

Duke Authors

Cited Authors

  • Hennerbichler, A; Moutos, FT; Hennerbichler, D; Weinberg, JB; Guilak, F

Published Date

  • September 2007

Published In

Volume / Issue

  • 15 / 9

Start / End Page

  • 1053 - 1060

PubMed ID

  • 17448702

International Standard Serial Number (ISSN)

  • 1063-4584

Digital Object Identifier (DOI)

  • 10.1016/j.joca.2007.03.003

Language

  • eng

Citation Source

  • PubMed