Skip to main content

Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis.

Publication ,  Journal Article
Webb, CP; Taylor, GA; Jeffers, M; Fiscella, M; Oskarsson, M; Resau, JH; Vande Woude, GF
Published in: Oncogene
October 22, 1998

Aberrations in Met-hepatocyte growth factor/scatter factor (HGF/SF) signaling have been implicated in the acquisition of tumorigenic and metastatic phenotypes. Here we show that murine NIH3T3 and C127 cells transformed by the Ras oncogene overexpress the Met receptor, resulting in enhanced HGF/SF-mediated responses in vitro including invasion through basement membrane. Accompanying the increase in Met in ras-transformed NIH3T3 cells, there is a decrease in endogenous HGF/SF expression as previously observed in cells exogenously overexpressing Met. However, subcutaneously grown tumors and experimental lung metastases derived from these cells express significantly higher levels of endogenous HGF/SF together with high levels of Met. These results suggest Met-HGF/SF signaling enhances tumor growth and metastasis of Ras-transformed NIH3T3 cells.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

October 22, 1998

Volume

17

Issue

16

Start / End Page

2019 / 2025

Location

England

Related Subject Headings

  • Proto-Oncogene Proteins c-met
  • Oncology & Carcinogenesis
  • Oncogene Protein p21(ras)
  • Mice, Nude
  • Mice, Knockout
  • Mice
  • Lung Neoplasms
  • Humans
  • Female
  • Dogs
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Webb, C. P., Taylor, G. A., Jeffers, M., Fiscella, M., Oskarsson, M., Resau, J. H., & Vande Woude, G. F. (1998). Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis. Oncogene, 17(16), 2019–2025. https://doi.org/10.1038/sj.onc.1202135
Webb, C. P., G. A. Taylor, M. Jeffers, M. Fiscella, M. Oskarsson, J. H. Resau, and G. F. Vande Woude. “Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis.Oncogene 17, no. 16 (October 22, 1998): 2019–25. https://doi.org/10.1038/sj.onc.1202135.
Webb CP, Taylor GA, Jeffers M, Fiscella M, Oskarsson M, Resau JH, et al. Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis. Oncogene. 1998 Oct 22;17(16):2019–25.
Webb, C. P., et al. “Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis.Oncogene, vol. 17, no. 16, Oct. 1998, pp. 2019–25. Pubmed, doi:10.1038/sj.onc.1202135.
Webb CP, Taylor GA, Jeffers M, Fiscella M, Oskarsson M, Resau JH, Vande Woude GF. Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis. Oncogene. 1998 Oct 22;17(16):2019–2025.

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

October 22, 1998

Volume

17

Issue

16

Start / End Page

2019 / 2025

Location

England

Related Subject Headings

  • Proto-Oncogene Proteins c-met
  • Oncology & Carcinogenesis
  • Oncogene Protein p21(ras)
  • Mice, Nude
  • Mice, Knockout
  • Mice
  • Lung Neoplasms
  • Humans
  • Female
  • Dogs