Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis.
Aberrations in Met-hepatocyte growth factor/scatter factor (HGF/SF) signaling have been implicated in the acquisition of tumorigenic and metastatic phenotypes. Here we show that murine NIH3T3 and C127 cells transformed by the Ras oncogene overexpress the Met receptor, resulting in enhanced HGF/SF-mediated responses in vitro including invasion through basement membrane. Accompanying the increase in Met in ras-transformed NIH3T3 cells, there is a decrease in endogenous HGF/SF expression as previously observed in cells exogenously overexpressing Met. However, subcutaneously grown tumors and experimental lung metastases derived from these cells express significantly higher levels of endogenous HGF/SF together with high levels of Met. These results suggest Met-HGF/SF signaling enhances tumor growth and metastasis of Ras-transformed NIH3T3 cells.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Proto-Oncogene Proteins c-met
- Oncology & Carcinogenesis
- Oncogene Protein p21(ras)
- Mice, Nude
- Mice, Knockout
- Mice
- Lung Neoplasms
- Humans
- Female
- Dogs
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Proto-Oncogene Proteins c-met
- Oncology & Carcinogenesis
- Oncogene Protein p21(ras)
- Mice, Nude
- Mice, Knockout
- Mice
- Lung Neoplasms
- Humans
- Female
- Dogs