Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases).
Published
Journal Article (Review)
IRG proteins (also known as p47 GTPases) are key mediators of interferon-gamma-induced resistance to pathogens. Absence of certain IRG proteins leads to profound susceptibility to protozoa and bacteria in mice. Underlying their roles in host resistance, IRG proteins regulate the processing of pathogen-containing vacuoles in host cells, and regulate hematopoiesis following infection.
Full Text
Duke Authors
Cited Authors
- Taylor, GA; Feng, CG; Sher, A
Published Date
- November 2007
Published In
Volume / Issue
- 9 / 14-15
Start / End Page
- 1644 - 1651
PubMed ID
- 18023232
Pubmed Central ID
- 18023232
International Standard Serial Number (ISSN)
- 1286-4579
Digital Object Identifier (DOI)
- 10.1016/j.micinf.2007.09.004
Language
- eng
Conference Location
- France