Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases).

Journal Article (Journal Article;Review)

IRG proteins (also known as p47 GTPases) are key mediators of interferon-gamma-induced resistance to pathogens. Absence of certain IRG proteins leads to profound susceptibility to protozoa and bacteria in mice. Underlying their roles in host resistance, IRG proteins regulate the processing of pathogen-containing vacuoles in host cells, and regulate hematopoiesis following infection.

Full Text

Duke Authors

Cited Authors

  • Taylor, GA; Feng, CG; Sher, A

Published Date

  • 2007

Published In

Volume / Issue

  • 9 / 14-15

Start / End Page

  • 1644 - 1651

PubMed ID

  • 18023232

International Standard Serial Number (ISSN)

  • 1286-4579

Digital Object Identifier (DOI)

  • 10.1016/j.micinf.2007.09.004


  • eng

Conference Location

  • France