Human IRGM induces autophagy to eliminate intracellular mycobacteria.
Journal Article (Journal Article)
Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.
Full Text
Duke Authors
Cited Authors
- Singh, SB; Davis, AS; Taylor, GA; Deretic, V
Published Date
- September 8, 2006
Published In
Volume / Issue
- 313 / 5792
Start / End Page
- 1438 - 1441
PubMed ID
- 16888103
Electronic International Standard Serial Number (EISSN)
- 1095-9203
Digital Object Identifier (DOI)
- 10.1126/science.1129577
Language
- eng
Conference Location
- United States