Human IRGM induces autophagy to eliminate intracellular mycobacteria.
Publication
, Journal Article
Singh, SB; Davis, AS; Taylor, GA; Deretic, V
Published in: Science
September 8, 2006
Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.
Duke Scholars
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Published In
Science
DOI
EISSN
1095-9203
Publication Date
September 8, 2006
Volume
313
Issue
5792
Start / End Page
1438 / 1441
Location
United States
Related Subject Headings
- Vacuoles
- Transfection
- RNA, Small Interfering
- Phagosomes
- Mycobacterium bovis
- Microtubule-Associated Proteins
- Microbial Viability
- Mice
- Macrophages
- Lysosomes
Citation
APA
Chicago
ICMJE
MLA
NLM
Singh, S. B., Davis, A. S., Taylor, G. A., & Deretic, V. (2006). Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science, 313(5792), 1438–1441. https://doi.org/10.1126/science.1129577
Singh, Sudha B., Alexander S. Davis, Gregory A. Taylor, and Vojo Deretic. “Human IRGM induces autophagy to eliminate intracellular mycobacteria.” Science 313, no. 5792 (September 8, 2006): 1438–41. https://doi.org/10.1126/science.1129577.
Singh SB, Davis AS, Taylor GA, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science. 2006 Sep 8;313(5792):1438–41.
Singh, Sudha B., et al. “Human IRGM induces autophagy to eliminate intracellular mycobacteria.” Science, vol. 313, no. 5792, Sept. 2006, pp. 1438–41. Pubmed, doi:10.1126/science.1129577.
Singh SB, Davis AS, Taylor GA, Deretic V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science. 2006 Sep 8;313(5792):1438–1441.
Published In
Science
DOI
EISSN
1095-9203
Publication Date
September 8, 2006
Volume
313
Issue
5792
Start / End Page
1438 / 1441
Location
United States
Related Subject Headings
- Vacuoles
- Transfection
- RNA, Small Interfering
- Phagosomes
- Mycobacterium bovis
- Microtubule-Associated Proteins
- Microbial Viability
- Mice
- Macrophages
- Lysosomes