Human IRGM induces autophagy to eliminate intracellular mycobacteria.

Journal Article (Journal Article)

Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.

Full Text

Duke Authors

Cited Authors

  • Singh, SB; Davis, AS; Taylor, GA; Deretic, V

Published Date

  • September 8, 2006

Published In

Volume / Issue

  • 313 / 5792

Start / End Page

  • 1438 - 1441

PubMed ID

  • 16888103

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.1129577

Language

  • eng

Conference Location

  • United States