Decreased fibronectin expression in Met/HGF-mediated tumorigenesis.

Journal Article (Journal Article)

The tyrosine kinase receptor Met and its ligand, hepatocyte growth factor (HGF)/scatter factor are involved in the etiology and progression of a number of human cancers. Coexpression of Met and HGF in mesenchymal cells increases the tumorigenic and metastatic potential of the cells. In the studies described here, we used differential display screening to identify changes in gene expression that are initiated by Met/HGF, and that may lead to these phenotypes. We learned that Met/HGF signaling resulted in greatly decreased fibronectin mRNA production in three different human and mouse tumor cell lines; these decreases in fibronectin mRNA were paralleled by decreases in fibronectin protein. We also found a progressive decrease in fibronectin in tumor explants and metastases derived from the Met/HGF transformed cells. The absence of fibronectin expression is a frequent cancer phenotype; our results indicate that decreases in fibronectin correlate with, but are not essential for, MetHGF/SF-mediated tumorigenesis.

Full Text

Duke Authors

Cited Authors

  • Taylor, GA; Jeffers, M; Webb, CP; Koo, HM; Anver, M; Sekiguchi, K; Vande Woude, GF

Published Date

  • September 3, 1998

Published In

Volume / Issue

  • 17 / 9

Start / End Page

  • 1179 - 1183

PubMed ID

  • 9764829

International Standard Serial Number (ISSN)

  • 0950-9232

Digital Object Identifier (DOI)

  • 10.1038/sj.onc.1202004


  • eng

Conference Location

  • England