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Decreased fibronectin expression in Met/HGF-mediated tumorigenesis.

Publication ,  Journal Article
Taylor, GA; Jeffers, M; Webb, CP; Koo, HM; Anver, M; Sekiguchi, K; Vande Woude, GF
Published in: Oncogene
September 3, 1998

The tyrosine kinase receptor Met and its ligand, hepatocyte growth factor (HGF)/scatter factor are involved in the etiology and progression of a number of human cancers. Coexpression of Met and HGF in mesenchymal cells increases the tumorigenic and metastatic potential of the cells. In the studies described here, we used differential display screening to identify changes in gene expression that are initiated by Met/HGF, and that may lead to these phenotypes. We learned that Met/HGF signaling resulted in greatly decreased fibronectin mRNA production in three different human and mouse tumor cell lines; these decreases in fibronectin mRNA were paralleled by decreases in fibronectin protein. We also found a progressive decrease in fibronectin in tumor explants and metastases derived from the Met/HGF transformed cells. The absence of fibronectin expression is a frequent cancer phenotype; our results indicate that decreases in fibronectin correlate with, but are not essential for, MetHGF/SF-mediated tumorigenesis.

Duke Scholars

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

September 3, 1998

Volume

17

Issue

9

Start / End Page

1179 / 1183

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Transforming Growth Factor beta
  • RNA, Messenger
  • Proto-Oncogene Proteins c-met
  • Oncology & Carcinogenesis
  • Neoplasms, Experimental
  • Mice, Nude
  • Mice
  • Humans
  • Hepatocyte Growth Factor
 

Citation

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Taylor, G. A., Jeffers, M., Webb, C. P., Koo, H. M., Anver, M., Sekiguchi, K., & Vande Woude, G. F. (1998). Decreased fibronectin expression in Met/HGF-mediated tumorigenesis. Oncogene, 17(9), 1179–1183. https://doi.org/10.1038/sj.onc.1202004
Taylor, G. A., M. Jeffers, C. P. Webb, H. M. Koo, M. Anver, K. Sekiguchi, and G. F. Vande Woude. “Decreased fibronectin expression in Met/HGF-mediated tumorigenesis.Oncogene 17, no. 9 (September 3, 1998): 1179–83. https://doi.org/10.1038/sj.onc.1202004.
Taylor GA, Jeffers M, Webb CP, Koo HM, Anver M, Sekiguchi K, et al. Decreased fibronectin expression in Met/HGF-mediated tumorigenesis. Oncogene. 1998 Sep 3;17(9):1179–83.
Taylor, G. A., et al. “Decreased fibronectin expression in Met/HGF-mediated tumorigenesis.Oncogene, vol. 17, no. 9, Sept. 1998, pp. 1179–83. Pubmed, doi:10.1038/sj.onc.1202004.
Taylor GA, Jeffers M, Webb CP, Koo HM, Anver M, Sekiguchi K, Vande Woude GF. Decreased fibronectin expression in Met/HGF-mediated tumorigenesis. Oncogene. 1998 Sep 3;17(9):1179–1183.

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

September 3, 1998

Volume

17

Issue

9

Start / End Page

1179 / 1183

Location

England

Related Subject Headings

  • Tumor Cells, Cultured
  • Transforming Growth Factor beta
  • RNA, Messenger
  • Proto-Oncogene Proteins c-met
  • Oncology & Carcinogenesis
  • Neoplasms, Experimental
  • Mice, Nude
  • Mice
  • Humans
  • Hepatocyte Growth Factor