IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens.


Journal Article (Review)

Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. The proteins are expressed at high levels following infection with bacteria, protozoa or viruses, as a consequence of interferon-stimulated transcription. Their absence in gene-targeted mice leads to profoundly decreased resistance to many bacteria and protozoa that varies markedly with the particular IRG protein that has been targeted. The proteins are thought to function by localizing to pathogen-containing vacuoles in host cells, such as macrophages, and then regulating the processing of the vacuole and ultimately driving elimination of the pathogen. This review details current knowledge of IRG proteins and their key roles in host resistance.

Full Text

Duke Authors

Cited Authors

  • Taylor, GA

Published Date

  • May 2007

Published In

Volume / Issue

  • 9 / 5

Start / End Page

  • 1099 - 1107

PubMed ID

  • 17359233

Pubmed Central ID

  • 17359233

International Standard Serial Number (ISSN)

  • 1462-5814

Digital Object Identifier (DOI)

  • 10.1111/j.1462-5822.2007.00916.x


  • eng

Conference Location

  • England