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Muscle atrophy in transgenic mice expressing a human TSC1 transgene.

Publication ,  Journal Article
Wan, M; Wu, X; Guan, K-L; Han, M; Zhuang, Y; Xu, T
Published in: FEBS Lett
October 16, 2006

Muscle mass is regulated by a wide range of hormonal and nutritional signals, such as insulin and IGF. Tuberous sclerosis complex (TSC) is an inherited hamartoma disease with tumor growth in numerous organs. TSC is caused by mutation in either TSC1 or TSC2 tumor suppressor genes that negatively regulate insulin-induced S6K activation and cell growth. Here we report that expression of human TSC1 (hTSC1) in mouse skeletal muscle leads to reduction of muscle mass. Expression of hTSC1 stabilizes endogenous TSC2 and leads to inhibition of the mTOR signaling. The hTSC1-mTSC2 hetero-complex and its downstream components remain sensitive to insulin stimulation and nutrition signals. This study suggests that an increase in the steady state level of resident TSC1-TSC2 complex is sufficient to reduce muscle mass and cause atrophy.

Duke Scholars

Published In

FEBS Lett

DOI

ISSN

0014-5793

Publication Date

October 16, 2006

Volume

580

Issue

24

Start / End Page

5621 / 5627

Location

England

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tuberous Sclerosis Complex 2 Protein
  • Tuberous Sclerosis Complex 1 Protein
  • Signal Transduction
  • Protein Binding
  • Organ Size
  • Muscular Atrophy
  • Mice, Transgenic
  • Mice
  • Male
 

Citation

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Wan, M., Wu, X., Guan, K.-L., Han, M., Zhuang, Y., & Xu, T. (2006). Muscle atrophy in transgenic mice expressing a human TSC1 transgene. FEBS Lett, 580(24), 5621–5627. https://doi.org/10.1016/j.febslet.2006.09.008
Wan, Min, Xiaohui Wu, Kun-Liang Guan, Min Han, Yuan Zhuang, and Tian Xu. “Muscle atrophy in transgenic mice expressing a human TSC1 transgene.FEBS Lett 580, no. 24 (October 16, 2006): 5621–27. https://doi.org/10.1016/j.febslet.2006.09.008.
Wan M, Wu X, Guan K-L, Han M, Zhuang Y, Xu T. Muscle atrophy in transgenic mice expressing a human TSC1 transgene. FEBS Lett. 2006 Oct 16;580(24):5621–7.
Wan, Min, et al. “Muscle atrophy in transgenic mice expressing a human TSC1 transgene.FEBS Lett, vol. 580, no. 24, Oct. 2006, pp. 5621–27. Pubmed, doi:10.1016/j.febslet.2006.09.008.
Wan M, Wu X, Guan K-L, Han M, Zhuang Y, Xu T. Muscle atrophy in transgenic mice expressing a human TSC1 transgene. FEBS Lett. 2006 Oct 16;580(24):5621–5627.
Journal cover image

Published In

FEBS Lett

DOI

ISSN

0014-5793

Publication Date

October 16, 2006

Volume

580

Issue

24

Start / End Page

5621 / 5627

Location

England

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tuberous Sclerosis Complex 2 Protein
  • Tuberous Sclerosis Complex 1 Protein
  • Signal Transduction
  • Protein Binding
  • Organ Size
  • Muscular Atrophy
  • Mice, Transgenic
  • Mice
  • Male