Eicosanoids: lipid mediators of inflammation in transplantation.

Journal Article (Journal Article;Review)

Eicosanoids are a family of lipid mediators derived from the metabolism of arachidonic acid. Eicosanoids, such as prostanoids and leukotrienes, have a wide range of biological actions including potent effects on inflammation and immunity. It has been almost 20 years since the first reports emerged suggesting a role for eicosanoids in transplantation. Since then, a number of functions have been ascribed to these mediators, ranging from immunomodulation to regulation of allograft hemodynamics. In this review, we will highlight the effects of eicosanoids in transplantation, focusing particularly on evidence provided by gene targeting studies. In the future, pharmacological manipulation of eicosanoids and their receptors may provide a novel approach for controlling inflammation and promoting allograft acceptance.

Full Text

Duke Authors

Cited Authors

  • Rocha, PN; Plumb, TJ; Coffman, TM

Published Date

  • September 2003

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 215 - 227

PubMed ID

  • 12955468

International Standard Serial Number (ISSN)

  • 0344-4325

Digital Object Identifier (DOI)

  • 10.1007/s00281-003-0132-4


  • eng

Conference Location

  • Germany