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Prostacyclin protects against elevated blood pressure and cardiac fibrosis.

Publication ,  Journal Article
Francois, H; Athirakul, K; Howell, D; Dash, R; Mao, L; Kim, H-S; Rockman, HA; Fitzgerald, GA; Koller, BH; Coffman, TM
Published in: Cell Metab
September 2005

Specific inhibitors of COX-2 have been associated with increased risk for cardiovascular complications. These agents reduce prostacyclin (PGI2) without affecting production of thromboxane (Tx) A2. While this abnormal pattern of eicosanoid generation has been implicated in the development of vascular disease associated with COX-2 inhibition, its role in the development of hypertension, the most common cardiovascular complication associated with COX-2 inhibition, is not known. We report here that mice lacking the receptor for PGI2 (IPKOs) develop salt-sensitive hypertension, cardiac hypertrophy, and severe cardiac fibrosis. Coincidental deletion of the TxA2 (TP) receptor does not prevent the development of hypertension, but cardiac hypertrophy is ameliorated and fibrosis is prevented in IPTP double knockouts (DKOs). Thus, deletion of the IP receptor removes a constraint revealing adverse cardiovascular consequences of TxA2. Our data suggest that adjuvant therapy that blocks unrestrained Tx actions might protect against end-organ damage without affecting blood pressure in patients taking COX-2 inhibitors.

Duke Scholars

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Published In

Cell Metab

DOI

ISSN

1550-4131

Publication Date

September 2005

Volume

2

Issue

3

Start / End Page

201 / 207

Location

United States

Related Subject Headings

  • Thromboxane B2
  • Sodium, Dietary
  • Renin
  • Radioimmunoassay
  • RNA, Messenger
  • Organ Size
  • Myocardium
  • Mice, Knockout
  • Mice
  • Male
 

Citation

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Francois, H., Athirakul, K., Howell, D., Dash, R., Mao, L., Kim, H.-S., … Coffman, T. M. (2005). Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metab, 2(3), 201–207. https://doi.org/10.1016/j.cmet.2005.08.005
Francois, Helene, Krairerk Athirakul, David Howell, Rajesh Dash, Lan Mao, Hyung-Suk Kim, Howard A. Rockman, Garret A. Fitzgerald, Beverly H. Koller, and Thomas M. Coffman. “Prostacyclin protects against elevated blood pressure and cardiac fibrosis.Cell Metab 2, no. 3 (September 2005): 201–7. https://doi.org/10.1016/j.cmet.2005.08.005.
Francois H, Athirakul K, Howell D, Dash R, Mao L, Kim H-S, et al. Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metab. 2005 Sep;2(3):201–7.
Francois, Helene, et al. “Prostacyclin protects against elevated blood pressure and cardiac fibrosis.Cell Metab, vol. 2, no. 3, Sept. 2005, pp. 201–07. Pubmed, doi:10.1016/j.cmet.2005.08.005.
Francois H, Athirakul K, Howell D, Dash R, Mao L, Kim H-S, Rockman HA, Fitzgerald GA, Koller BH, Coffman TM. Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metab. 2005 Sep;2(3):201–207.
Journal cover image

Published In

Cell Metab

DOI

ISSN

1550-4131

Publication Date

September 2005

Volume

2

Issue

3

Start / End Page

201 / 207

Location

United States

Related Subject Headings

  • Thromboxane B2
  • Sodium, Dietary
  • Renin
  • Radioimmunoassay
  • RNA, Messenger
  • Organ Size
  • Myocardium
  • Mice, Knockout
  • Mice
  • Male