Self-phase modulation signatures of neuronal activity.


Journal Article

We use phase-sensitive detection of spectral hole refilling to demonstrate strong novel intrinsic nonlinear signatures of neuronal activation in hippocampal brain slices. The ability to gain access to this fundamentally new intrinsic contrast with modest power levels suggests a new approach to in vivo neural imaging. We expect that we can extrapolate our method to high spatial and temporal resolution in deep tissue while retaining the noninvasive character.

Full Text

Duke Authors

Cited Authors

  • Fischer, MC; Liu, HC; Piletic, IR; Escobedo-Lozoya, Y; Yasuda, R; Warren, WS

Published Date

  • February 2008

Published In

Volume / Issue

  • 33 / 3

Start / End Page

  • 219 - 221

PubMed ID

  • 18246134

Pubmed Central ID

  • 18246134

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

International Standard Serial Number (ISSN)

  • 0146-9592

Digital Object Identifier (DOI)

  • 10.1364/ol.33.000219


  • eng