Regression models for prognostic prediction: advantages, problems, and suggested solutions.

Published

Journal Article

Multiple regression models have wide applicability in predicting the outcome of patients with a variety of diseases. However, many researchers are using such models without validating the necessary assumptions. All too frequently, researchers also "overfit" the data by developing models using too many predictor variables and insufficient sample sizes. Models developed in this way are unlikely to stand the test of validation on a separate patient sample. Without attempting such a validation, the researcher remains unaware that overfitting has occurred. When the ratio of the number of patients suffering endpoints to the number of potential predictors is small (say less than 10), data reduction methods are available that can greatly improve the performance of regression models. Regression models can make more accurate predictions than other methods such as stratification and recursive partitioning, when model assumptions are thoroughly examined; steps are taken (ie, choosing another model or transforming the data) when assumptions are violated; and the method of model formulation does not result in overfitting the data.

Full Text

Duke Authors

Cited Authors

  • Harrell, FE; Lee, KL; Matchar, DB; Reichert, TA

Published Date

  • October 1, 1985

Published In

Volume / Issue

  • 69 / 10

Start / End Page

  • 1071 - 1077

PubMed ID

  • 4042087

Pubmed Central ID

  • 4042087

International Standard Serial Number (ISSN)

  • 0361-5960

Language

  • eng