Similar CD19 dysregulation in two autoantibody-associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss.

Published

Journal Article

: We report here that dysregulation of CD19, a coreceptor that augments B-cell receptor (BCR) signaling, occurs at two B-cell differentiative stages in patients with systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic autoantibody (ANCA) associated small vessel vasculitis (SVV). The naïve B cells of nearly all SLE and ANCA-SVV patients express approximately 20% less CD19 than healthy control (HC) B cells. In contrast, a subset of memory B cells of some SLE and ANCA-SVV Pts (25-35%) express two to fourfold more CD19 than HC B cells. These CD19(hi) memory B cells are activated and exhibit evidence of antigen selection. Proteome array analysis of 67 autoantigens indicates that CD19(hi) SLE Pts exhibit a distinct autoantibody profile characterized by high levels of antibodies to small nuclear ribonucleoproteins and low levels of antiglomerular autoantibodies. These findings have implications for autoreactive B-cell activation and suggest a shared mechanism of B-cell tolerance loss in these two diseases.

Full Text

Duke Authors

Cited Authors

  • Culton, DA; Nicholas, MW; Bunch, DO; Zhen, QL; Kepler, TB; Dooley, MA; Mohan, C; Nachman, PH; Clarke, SH

Published Date

  • January 1, 2007

Published In

Volume / Issue

  • 27 / 1

Start / End Page

  • 53 - 68

PubMed ID

  • 17195045

Pubmed Central ID

  • 17195045

International Standard Serial Number (ISSN)

  • 0271-9142

Digital Object Identifier (DOI)

  • 10.1007/s10875-006-9051-1

Language

  • eng

Conference Location

  • Netherlands