CD22 regulates time course of both B cell division and antibody response.


Journal Article

Because pathogens induce infectious symptoms in a time-dependent manner, a rapid immune response is beneficial for defending hosts from pathogens, especially those inducing acute infectious diseases. However, it is largely unknown how the time course of immune responses is regulated. In this study, we demonstrate that B cells deficient in the inhibitory coreceptor CD22 undergo accelerated cell division after Ag stimulation, resulting in rapid generation of plasma cells and Ab production. This finding indicates that CD22 regulates the time course of B cell responses and suggests that CD22 is a good target to shorten the time required for Ab production, thereby augmenting host defense against acute infectious diseases as "universal vaccination."

Full Text

Duke Authors

Cited Authors

  • Onodera, T; Poe, JC; Tedder, TF; Tsubata, T

Published Date

  • January 15, 2008

Published In

Volume / Issue

  • 180 / 2

Start / End Page

  • 907 - 913

PubMed ID

  • 18178830

Pubmed Central ID

  • 18178830

International Standard Serial Number (ISSN)

  • 0022-1767

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.180.2.907


  • eng

Conference Location

  • United States