B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice.

Journal Article (Journal Article)

Sjögren's syndrome is an autoimmune disease in which immune cells chronically attack the lachrymal and salivary glands. The Id3 knockout mouse is a newly established animal model for primary Sjögren's syndrome. To address the role of B cells in Sjögren's syndrome and autoimmune disease, we studied the effect of CD20 monoclonal antibody treatment on the disease in Id3 knockout mice. Antibody treatment at 2-month intervals led to efficient and sustained B-cell depletion in Id3 knockout mice. A significant improvement of histopathology was observed accompanied by the recovery of saliva secretory function after CD20 antibody treatment. We further show that serum immunoglobulin G3, which is abnormally high in untreated Id3 knockout mice, was reduced after CD20 antibody treatment. This study establishes a new animal model for immunotherapy of Sjögren's symptoms and suggests a possible link between immunoglobulin G3 and disease pathology in Id3 knockout mice.

Full Text

Duke Authors

Cited Authors

  • Hayakawa, I; Tedder, TF; Zhuang, Y

Published Date

  • September 2007

Published In

Volume / Issue

  • 122 / 1

Start / End Page

  • 73 - 79

PubMed ID

  • 17472721

Pubmed Central ID

  • PMC2265983

International Standard Serial Number (ISSN)

  • 0019-2805

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2567.2007.02614.x


  • eng

Conference Location

  • England