On the memory of a chronic illness.

Published online

Journal Article (Review)

The elderly are particularly susceptible to disease, yet the biological mechanisms that bring about this susceptibility remain unclear. Using atherosclerosis as a model chronic illness, we review how recent studies of bone marrow-derived vascular repair systems in mice and humans provide new insights into the causes and potential cures for age-related illness. Organisms are born with a finite capacity for stem cell-mediated repair after chronic exposure to tissue injury. Once that capacity is exhausted, a cycle of pathological inflammation ensues and leads to overt disease manifestations. Augmentation of stem cell-mediated repair systems may provide a novel means of treating or preventing many age-related illnesses.

Full Text

Duke Authors

Cited Authors

  • Goldschmidt-Clermont, PJ; Peterson, ED

Published Date

  • November 12, 2003

Published In

Volume / Issue

  • 2003 / 45

Start / End Page

  • re8 -

PubMed ID

  • 14614128

Pubmed Central ID

  • 14614128

Electronic International Standard Serial Number (EISSN)

  • 1539-6150

Digital Object Identifier (DOI)

  • 10.1126/sageke.2003.45.re8


  • eng

Conference Location

  • United States