Integrating antithrombin and antiplatelet therapies with early invasive management for non-ST-segment elevation acute coronary syndromes.


Journal Article (Review)

Non-ST-segment elevation acute coronary syndromes are a dramatic manifestation of coronary artery disease. Multiple clinical trials have shown that early cardiac catheterization improves clinical outcomes in patients with non-ST-segment elevation acute coronary syndromes. Many antithrombotic agents effectively manage unstable coronary syndromes and serve as adjuncts to percutaneous coronary intervention. Yet, the growing number of pharmacologic agents makes early management of non-ST-segment elevation acute coronary syndromes increasingly complex. We review the current evidence regarding the optimal integration of early antithrombotic and antiplatelet therapies with early coronary angiography and subsequent revascularization.

Full Text

Duke Authors

Cited Authors

  • Rebeiz, AG; Roe, MT; Alexander, JH; Mahaffey, KW; Granger, CB; Peterson, ED; Califf, RM; Harrington, RA

Published Date

  • January 15, 2004

Published In

Volume / Issue

  • 116 / 2

Start / End Page

  • 119 - 129

PubMed ID

  • 14715326

Pubmed Central ID

  • 14715326

International Standard Serial Number (ISSN)

  • 0002-9343

Digital Object Identifier (DOI)

  • 10.1016/j.amjmed.2003.09.028


  • eng

Conference Location

  • United States