The discovery of adult progenitor cells capable of generating new vascular and myocardial tissue offers the promise of salvage of ischaemically threatened or irreversibly damaged cardiac tissue. Not surprisingly, great interest has focused on the use of a variety of cell types to treat both acute myocardial infarction and chronic ischaemic heart disease. This review focuses on the treatment of these two categories of disease, the cell types being considered, our understanding of timing and methods of cellular administration, and possible mechanisms of myocardial salvage.