Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

Published

Journal Article

Human interleukin (IL) 1 receptor-associated kinase 4 (IRAK-4) deficiency is a recently discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll-like receptor (TLR) 3- and TLR4-interferon (IFN)-alpha/beta pathways. The clinical and immunological phenotype remains largely unknown. We diagnosed up to 28 patients with IRAK-4 deficiency, tested blood TLR responses for individual leukocyte subsets, and TLR responses for multiple cytokines. The patients' peripheral blood mononuclear cells (PBMCs) did not induce the 11 non-IFN cytokines tested upon activation with TLR agonists other than the nonspecific TLR3 agonist poly(I:C). The patients' individual cell subsets from both myeloid (granulocytes, monocytes, monocyte-derived dendritic cells [MDDCs], myeloid DCs [MDCs], and plasmacytoid DCs) and lymphoid (B, T, and NK cells) lineages did not respond to the TLR agonists that stimulated control cells, with the exception of residual responses to poly(I:C) and lipopolysaccharide in MDCs and MDDCs. Most patients (22 out of 28; 79%) suffered from invasive pneumococcal disease, which was often recurrent (13 out of 22; 59%). Other infections were rare, with the exception of severe staphylococcal disease (9 out of 28; 32%). Almost half of the patients died (12 out of 28; 43%). No death and no invasive infection occurred in patients older than 8 and 14 yr, respectively. The IRAK-4-dependent TLRs and IL-1Rs are therefore vital for childhood immunity to pyogenic bacteria, particularly Streptococcus pneumoniae. Conversely, IRAK-4-dependent human TLRs appear to play a redundant role in protective immunity to most infections, at most limited to childhood immunity to some pyogenic bacteria.

Full Text

Duke Authors

Cited Authors

  • Ku, C-L; von Bernuth, H; Picard, C; Zhang, S-Y; Chang, H-H; Yang, K; Chrabieh, M; Issekutz, AC; Cunningham, CK; Gallin, J; Holland, SM; Roifman, C; Ehl, S; Smart, J; Tang, M; Barrat, FJ; Levy, O; McDonald, D; Day-Good, NK; Miller, R; Takada, H; Hara, T; Al-Hajjar, S; Al-Ghonaium, A; Speert, D; Sanlaville, D; Li, X; Geissmann, F; Vivier, E; Maródi, L; Garty, B-Z; Chapel, H; Rodriguez-Gallego, C; Bossuyt, X; Abel, L; Puel, A; Casanova, J-L

Published Date

  • October 1, 2007

Published In

Volume / Issue

  • 204 / 10

Start / End Page

  • 2407 - 2422

PubMed ID

  • 17893200

Pubmed Central ID

  • 17893200

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.20070628

Language

  • eng

Conference Location

  • United States