Neonates support lymphopenia-induced proliferation.

Published

Journal Article

T cells expand without intentional antigen stimulation when transferred into adult lymphopenic environments. In this study, we show that the physiologic lymphopenic environment existing in neonatal mice also supports CD4 T cell proliferation. Strikingly, naive CD4 T cells that proliferate within neonates acquire the phenotypic and functional characteristics of memory cells. Such proliferation is inhibited by the presence of both memory and naive CD4 T cells, is enhanced by 3-day thymectomy, is independent of IL-7, and requires a class II MHC-TCR interaction and a CD28-mediated signal. CD44(bright) CD4 T cells in neonates have a wide repertoire as judged by the distribution of Vbeta expression. Thus, lymphopenia-induced T cell proliferation is a physiologic process that occurs during the early postnatal period.

Full Text

Duke Authors

Cited Authors

  • Min, B; McHugh, R; Sempowski, GD; Mackall, C; Foucras, G; Paul, WE

Published Date

  • January 2003

Published In

Volume / Issue

  • 18 / 1

Start / End Page

  • 131 - 140

PubMed ID

  • 12530982

Pubmed Central ID

  • 12530982

Electronic International Standard Serial Number (EISSN)

  • 1097-4180

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(02)00508-3

Language

  • eng