Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease.
Published
Journal Article
The major challenge in allogeneic hematopoietic cell transplantation is how to transfer allogeneic T-cell immunity without causing graft-versus-host disease (GVHD). Here we report a novel strategy to selectively prevent GVHD by depleting CD62L(+) T cells (naive and a subset of memory T cells). In unprimed mice, CD62L(-) T cells (a subset of memory T cells) failed to proliferate in response to alloantigens (which the mice have never previously encountered) and were unable to induce GVHD in allogeneic hosts. CD62L(-) T cells contributed to T-cell reconstitution by peripheral expansion as well as by promoting T-cell regeneration from bone marrow stem/progenitor cells. CD62L(-) T cells from the animals previously primed with a tumor cell line (BCL1) were able to inhibit the tumor growth in vivo but were unable to induce GVHD in the third-party recipients. This novel technology may allow transfer of allogeneic recall antitumor and antimicrobial immunity without causing GVHD.
Full Text
Duke Authors
Cited Authors
- Chen, BJ; Cui, X; Sempowski, GD; Liu, C; Chao, NJ
Published Date
- February 15, 2004
Published In
Volume / Issue
- 103 / 4
Start / End Page
- 1534 - 1541
PubMed ID
- 14551132
Pubmed Central ID
- 14551132
International Standard Serial Number (ISSN)
- 0006-4971
Digital Object Identifier (DOI)
- 10.1182/blood-2003-08-2987
Language
- eng
Conference Location
- United States