Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease.

Journal Article

The major challenge in allogeneic hematopoietic cell transplantation is how to transfer allogeneic T-cell immunity without causing graft-versus-host disease (GVHD). Here we report a novel strategy to selectively prevent GVHD by depleting CD62L(+) T cells (naive and a subset of memory T cells). In unprimed mice, CD62L(-) T cells (a subset of memory T cells) failed to proliferate in response to alloantigens (which the mice have never previously encountered) and were unable to induce GVHD in allogeneic hosts. CD62L(-) T cells contributed to T-cell reconstitution by peripheral expansion as well as by promoting T-cell regeneration from bone marrow stem/progenitor cells. CD62L(-) T cells from the animals previously primed with a tumor cell line (BCL1) were able to inhibit the tumor growth in vivo but were unable to induce GVHD in the third-party recipients. This novel technology may allow transfer of allogeneic recall antitumor and antimicrobial immunity without causing GVHD.

Full Text

Duke Authors

Cited Authors

  • Chen, BJ; Cui, X; Sempowski, GD; Liu, C; Chao, NJ

Published Date

  • February 15, 2004

Published In

Volume / Issue

  • 103 / 4

Start / End Page

  • 1534 - 1541

PubMed ID

  • 14551132

International Standard Serial Number (ISSN)

  • 0006-4971

Digital Object Identifier (DOI)

  • 10.1182/blood-2003-08-2987

Language

  • eng

Conference Location

  • United States