Fibroblast heterogeneity in the healing wound.


Journal Article

Although fibroblasts are traditionally described as static cells providing framework and support for tissues, there is an accumulating body of evidence showing that fibroblasts are a dynamic cell type which exist in functionally and morphologically heterogeneous subpopulations. Fibroblast subsets have been shown to play a critical role in the production and regulation of extracellular matrix components, in wound repair and regeneration, and have been implicated in the pathogenesis of fibrotic conditions. We have reviewed the evidence supporting heterogeneity of fibroblasts from pulmonary, periodontal, and dermal tissues. In addition, we will explore the role fibroblast subpopulations may play in the complex process of wound repair and regeneration.

Full Text

Duke Authors

Cited Authors

  • Sempowski, GD; Borrello, MA; Blieden, TM; Barth, RK; Phipps, RP

Published Date

  • April 1995

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 120 - 131

PubMed ID

  • 17173641

Pubmed Central ID

  • 17173641

International Standard Serial Number (ISSN)

  • 1067-1927

Digital Object Identifier (DOI)

  • 10.1046/j.1524-475X.1995.30204.x


  • eng

Conference Location

  • United States