Exercise therapy for depression in middle-aged and older adults: predictors of early dropout and treatment failure.

Journal Article (Clinical Trial;Journal Article)

Psychosocial factors predicting treatment dropout or failure to benefit from treatment were identified in a randomized trial of exercise therapy and pharmacotherapy for major depression. One hundred fifty-six men and women over age 50 diagnosed with major depressive disorder were assigned to a 16-week program of aerobic exercise, medication (sertraline), or a combination of exercise and medication. Thirty-two patients (21%) failed to complete the program and were considered treatment "dropouts." At the end of 16 weeks, 83 patients (53%) were in remission; the remaining patients not in remission were considered treatment "failures." Baseline levels of self-reported anxiety and lift satisfaction were the best predictors of both patient dropout and treatment success or failure across all treatment conditions.

Full Text

Duke Authors

Cited Authors

  • Herman, S; Blumenthal, JA; Babyak, M; Khatri, P; Craighead, WE; Krishnan, KR; Doraiswamy, PM

Published Date

  • November 2002

Published In

Volume / Issue

  • 21 / 6

Start / End Page

  • 553 - 563

PubMed ID

  • 12433007

International Standard Serial Number (ISSN)

  • 0278-6133


  • eng

Conference Location

  • United States