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Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning.

Publication ,  Journal Article
Blumenthal, JA; Sherwood, A; Gullette, EC; Babyak, M; Waugh, R; Georgiades, A; Craighead, LW; Tweedy, D; Feinglos, M; Appelbaum, M; Hayano, J ...
Published in: Arch Intern Med
July 10, 2000

BACKGROUND: Lifestyle modifications have been recommended as the initial treatment strategy for lowering high blood pressure (BP). However, evidence for the efficacy of exercise and weight loss in the management of high BP remains controversial. METHODS: One hundred thirty-three sedentary, overweight men and women with unmedicated high normal BP or stage 1 to 2 hypertension were randomly assigned to aerobic exercise only; a behavioral weight management program, including exercise; or a waiting list control group. Before and following treatment, systolic and diastolic BPs were measured in the clinic, during daily life, and during exercise and mental stress testing. Hemodynamic measures and metabolic functioning also were assessed. RESULTS: Although participants in both active treatment groups exhibited significant reductions in BP relative to controls, those in the weight management group generally had larger reductions. Weight management was associated with a 7-mm Hg systolic and a 5-mm Hg diastolic clinic BP reduction, compared with a 4-mm Hg systolic and diastolic BP reduction associated with aerobic exercise; the BP for controls did not change. Participants in both treatment groups also displayed reduced peripheral resistance and increased cardiac output compared with controls, with the greatest reductions in peripheral resistance in those in the weight management group. Weight management participants also exhibited significantly lower fasting and postprandial glucose and insulin levels than participants in the other groups. CONCLUSIONS: Although exercise alone was effective in reducing BP, the addition of a behavioral weight loss program enhanced this effect. Aerobic exercise combined with weight loss is recommended for the management of elevated BP in sedentary, overweight individuals.

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Published In

Arch Intern Med

DOI

ISSN

0003-9926

Publication Date

July 10, 2000

Volume

160

Issue

13

Start / End Page

1947 / 1958

Location

United States

Related Subject Headings

  • Weight Loss
  • Waiting Lists
  • Treatment Outcome
  • Severity of Illness Index
  • Patient Compliance
  • Obesity
  • Middle Aged
  • Male
  • Life Style
  • Insulin
 

Citation

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Blumenthal, J. A., Sherwood, A., Gullette, E. C., Babyak, M., Waugh, R., Georgiades, A., … Hinderliter, A. (2000). Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning. Arch Intern Med, 160(13), 1947–1958. https://doi.org/10.1001/archinte.160.13.1947
Blumenthal, J. A., A. Sherwood, E. C. Gullette, M. Babyak, R. Waugh, A. Georgiades, L. W. Craighead, et al. “Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning.Arch Intern Med 160, no. 13 (July 10, 2000): 1947–58. https://doi.org/10.1001/archinte.160.13.1947.
Blumenthal JA, Sherwood A, Gullette EC, Babyak M, Waugh R, Georgiades A, et al. Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning. Arch Intern Med. 2000 Jul 10;160(13):1947–58.
Blumenthal, J. A., et al. “Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning.Arch Intern Med, vol. 160, no. 13, July 2000, pp. 1947–58. Pubmed, doi:10.1001/archinte.160.13.1947.
Blumenthal JA, Sherwood A, Gullette EC, Babyak M, Waugh R, Georgiades A, Craighead LW, Tweedy D, Feinglos M, Appelbaum M, Hayano J, Hinderliter A. Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning. Arch Intern Med. 2000 Jul 10;160(13):1947–1958.

Published In

Arch Intern Med

DOI

ISSN

0003-9926

Publication Date

July 10, 2000

Volume

160

Issue

13

Start / End Page

1947 / 1958

Location

United States

Related Subject Headings

  • Weight Loss
  • Waiting Lists
  • Treatment Outcome
  • Severity of Illness Index
  • Patient Compliance
  • Obesity
  • Middle Aged
  • Male
  • Life Style
  • Insulin