Memory performance by mild hypertensives following beta-adrenergic blockade.

Journal Article (Clinical Trial;Journal Article)

Previous experiments have reported deficits in cognitive performance following the administration of beta-adrenoceptor antagonists. These deficits have not appeared consistently, however, and it is not clear from previous studies whether changes in the central nervous system, rather than end-organ functioning, are responsible. The present experiment investigated the effects of beta blockade in a memory-search paradigm that distinguished the relatively central process of memory comparison from the more peripheral processes of stimulus encoding and response selection. Twenty-six adult men with mild essential hypertension received either a placebo or a beta blocker (atenolol or propranolol) for 2 weeks. Although beta blockade did occur in the active drug groups, there were no significant effects of the drugs on memory-search performance.

Full Text

Duke Authors

Cited Authors

  • Madden, DJ; Blumenthal, JA; Ekelund, LG; Krantz, DS; Light, KC; McKee, DC

Published Date

  • 1986

Published In

Volume / Issue

  • 89 / 1

Start / End Page

  • 20 - 24

PubMed ID

  • 3090588

International Standard Serial Number (ISSN)

  • 0033-3158

Digital Object Identifier (DOI)

  • 10.1007/BF00175183


  • eng

Conference Location

  • Germany