Association of physical fitness and transient myocardial ischemia in patients with coronary artery disease.

Journal Article (Journal Article)

PURPOSE: To examine the relationship between physical fitness and transient myocardial ischemia (TMI) in the laboratory and during daily life, in a sample of coronary patients with a recent positive exercise test. METHODS: 47 patients with coronary disease (CAD) participated in laboratory mental and exercise stress testing and 48-hour outpatient Holter monitoring after being withdrawn from ant-ischemic medications. During laboratory testing, left ventricular performance was assessed by radionuclide ventriculography. Physical fitness was assessed by measurement of oxygen consumption during symptom-limited exercise treadmill testing. RESULTS: Higher physical fitness subjects were less likely to exhibit wall-motion abnormalities in response to mental stress (P < .05), and to exercise stress (P < .05) testing. They also had smaller decreases in left ventricular ejection fraction (LVEF) in response to mental stress than less fit subjects (P .056), and exhibited a mean increase in LVEF during exercise, compared to the less fit subjects who exhibited a decrease in LVEF (P < .02). Moreover, higher fit subjects exhibited fewer episodes of TMI (P < .04), for a shorter duration (P < .04), and less total ischemic burden (P < .04) during Holter monitoring. CONCLUSION: These findings suggest that within a population of CAD patients, higher levels of physical fitness are associated with less TMI assessed in the laboratory and during routine activities of daily living.

Full Text

Duke Authors

Cited Authors

  • Jiang, W; Trauner, MA; Coleman, RE; Waugh, RA; Hanson, MW; Frid, DJ; Phillips, BG; Morris, JJ; O'Connor, C; Blumenthal, JA

Published Date

  • 1995

Published In

Volume / Issue

  • 15 / 6

Start / End Page

  • 431 - 438

PubMed ID

  • 8624970

International Standard Serial Number (ISSN)

  • 0883-9212

Digital Object Identifier (DOI)

  • 10.1097/00008483-199511000-00007


  • eng

Conference Location

  • United States