Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months.

Published

Journal Article

OBJECTIVE: The purpose of this study was to assess the status of 156 adult volunteers with major depressive disorder (MDD) 6 months after completion of a study in which they were randomly assigned to a 4-month course of aerobic exercise, sertraline therapy, or a combination of exercise and sertraline. METHODS: The presence and severity of depression were assessed by clinical interview using the Diagnostic Interview Schedule and the Hamilton Rating Scale for Depression (HRSD) and by self-report using the Beck Depression Inventory. Assessments were performed at baseline, after 4 months of treatment, and 6 months after treatment was concluded (ie, after 10 months). RESULTS: After 4 months patients in all three groups exhibited significant improvement; the proportion of remitted participants (ie, those who no longer met diagnostic criteria for MDD and had an HRSD score <8) was comparable across the three treatment conditions. After 10 months, however, remitted subjects in the exercise group had significantly lower relapse rates (p = .01) than subjects in the medication group. Exercising on one's own during the follow-up period was associated with a reduced probability of depression diagnosis at the end of that period (odds ratio = 0.49, p = .0009). CONCLUSIONS: Among individuals with MDD, exercise therapy is feasible and is associated with significant therapeutic benefit, especially if exercise is continued over time.

Full Text

Duke Authors

Cited Authors

  • Babyak, M; Blumenthal, JA; Herman, S; Khatri, P; Doraiswamy, M; Moore, K; Craighead, WE; Baldewicz, TT; Krishnan, KR

Published Date

  • September 2000

Published In

Volume / Issue

  • 62 / 5

Start / End Page

  • 633 - 638

PubMed ID

  • 11020092

Pubmed Central ID

  • 11020092

Electronic International Standard Serial Number (EISSN)

  • 1534-7796

International Standard Serial Number (ISSN)

  • 0033-3174

Digital Object Identifier (DOI)

  • 10.1097/00006842-200009000-00006

Language

  • eng