Functional changes after photodynamic therapy with verteporfin.


Journal Article

To investigate image preferences after photodynamic therapy (PDT).Prospective, cross-sectional study.Seventeen patients with neovascular age-related macular degeneration were tested by color vision, contrast sensitivity, and near visual acuity (VA) with positive images and negative images before, 1 week after, and 3 months after PDT.Before PDT, 13 patients (76%) preferred positive images; the difference was not significant (P < .04). One week after PDT, 16 patients (94%) preferred negative images. The average near VA improved to 27 letters on positive images and to 32 letters on negative images (P < .00001). Three months after PDT, near VA declined to 19 letters on positive images and to 26 letters on negative images (P < .000001). Color vision and contrast sensitivity remained constant during all examinations.Although PDT may not alter the neurosensory retina, it may affect intraretinal function by changing image preference.

Full Text

Duke Authors

Cited Authors

  • Meyer, CH; Lapolice, DJ; Fekrat, S

Published Date

  • January 2005

Published In

Volume / Issue

  • 139 / 1

Start / End Page

  • 214 - 215

PubMed ID

  • 15652863

Pubmed Central ID

  • 15652863

Electronic International Standard Serial Number (EISSN)

  • 1879-1891

International Standard Serial Number (ISSN)

  • 0002-9394

Digital Object Identifier (DOI)

  • 10.1016/j.ajo.2004.07.034


  • eng