Clinicopathologic correlation of an epiretinal membrane associated with a recurrent macular hole.
PURPOSE: To describe the clinicopathologic features of an epiretinal membrane associated with a recurrent, full-thickness idiopathic macular hole and speculate on the mechanism(s) contributing to its recurrence 1 year after initially successful closure of pars plana vitrectomy and gas tamponade (SF6). METHODS: After fixation of the 2 x 1 mm specimen in a mixture of 1% glutaraldehyde and 4% formaldehyde followed by 2.5% glutaraldehyde, postfixation with osmium tetroxide, and standard dehydration, the specimen was embedded in epoxy resin. Ultrathin sections were stained with uranyl acetate and lead citrate for transmission electron microscopy. RESULTS: Ultrastructural examination disclosed a fibrocellular membrane composed of Müller cells and fibrous astrocytes. Native collagen was entrapped in the matrix in some areas. CONCLUSION: Those cells that may lead to the closure of an idiopathic macular hole may also contribute to its recurrence if the reparative process goes awry.
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Related Subject Headings
- Vitrectomy
- Visual Acuity
- Sulfur Hexafluoride
- Retinal Perforations
- Retina
- Recurrence
- Ophthalmology & Optometry
- Middle Aged
- Humans
- Fundus Oculi
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Vitrectomy
- Visual Acuity
- Sulfur Hexafluoride
- Retinal Perforations
- Retina
- Recurrence
- Ophthalmology & Optometry
- Middle Aged
- Humans
- Fundus Oculi