Clinicopathologic correlation of an epiretinal membrane associated with a recurrent macular hole.

Journal Article (Journal Article)

PURPOSE: To describe the clinicopathologic features of an epiretinal membrane associated with a recurrent, full-thickness idiopathic macular hole and speculate on the mechanism(s) contributing to its recurrence 1 year after initially successful closure of pars plana vitrectomy and gas tamponade (SF6). METHODS: After fixation of the 2 x 1 mm specimen in a mixture of 1% glutaraldehyde and 4% formaldehyde followed by 2.5% glutaraldehyde, postfixation with osmium tetroxide, and standard dehydration, the specimen was embedded in epoxy resin. Ultrathin sections were stained with uranyl acetate and lead citrate for transmission electron microscopy. RESULTS: Ultrastructural examination disclosed a fibrocellular membrane composed of Müller cells and fibrous astrocytes. Native collagen was entrapped in the matrix in some areas. CONCLUSION: Those cells that may lead to the closure of an idiopathic macular hole may also contribute to its recurrence if the reparative process goes awry.

Full Text

Duke Authors

Cited Authors

  • Fekrat, S; Wendel, RT; de la Cruz, Z; Green, WR

Published Date

  • 1995

Published In

Volume / Issue

  • 15 / 1

Start / End Page

  • 53 - 57

PubMed ID

  • 7754248

International Standard Serial Number (ISSN)

  • 0275-004X

Digital Object Identifier (DOI)

  • 10.1097/00006982-199515010-00010


  • eng

Conference Location

  • United States