Selective inhibition of the duck hepatitis B virus by a new class of tetraazamacrocycles.

Journal Article (Journal Article)

The antiviral activity of a new class of N,N,N',N",NA'''-pentakis (omega-aminoalkyl) tetraazamacrocycles was evaluated in primary duck hepatocyte cultures infected with the duck hepatitis B virus (DHBV). Three of the four tested compounds were able to selectively inhibit DHBV replication by acting at an early step of the hepadnavirus infection but were associated with significant toxicity.

Full Text

Duke Authors

Cited Authors

  • Hantz, O; Borel, C; Trabaud, C; Zoulim, F; Dessolin, J; Camplo, M; Vlieghe, P; Bouygues, M; Trepo, C; Kraus, JL

Published Date

  • November 1997

Published In

Volume / Issue

  • 41 / 11

Start / End Page

  • 2579 - 2581

PubMed ID

  • 9371374

Pubmed Central ID

  • PMC164169

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.41.11.2579


  • eng

Conference Location

  • United States