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Alterations in natural anticoagulant levels during allogeneic bone marrow transplantation: a prospective study in 27 patients.

Publication ,  Journal Article
Leblond, V; Salehian, BD; Borel, C; Mapakou, CP; Dombret, H; Sutton, L; Binet, JL; Ankri, A
Published in: Bone Marrow Transplant
April 1993

The natural anticoagulants (antithrombin III, protein C, protein S), plasminogen and tissue plasminogen activator antigen (t-PA ag), were measured in 27 consecutive patients following allogeneic BMT. Thrombosis and veno-occlusive disease were not seen in this study. Changes in the levels of these proteins occurred mainly during acute GVHD. There were 14 patients who had no acute GVHD (group I) and 13 patients who had acute GVHD (group II). No changes in antithrombin III (ATIII), protein C, protein S and t-PA levels were found in group II before the appearance of acute GVHD when compared with group I. However, we noted a significant rise in protein S (p = 0.01), antithrombin III (p = 0.001) and t-PA ag (p = 0.0004) levels during acute GVHD. In contrast, protein C levels decreased early in GVHD (p = 0.005), and then increased progressively over the course of a month post-GVHD. No changes in plasminogen levels were observed. These results might reflect activation of and/or damage to endothelial cells during GVHD.

Duke Scholars

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

April 1993

Volume

11

Issue

4

Start / End Page

299 / 305

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Tissue Plasminogen Activator
  • Protein S
  • Protein C
  • Prospective Studies
  • Plasminogen
  • Middle Aged
  • Male
  • Immunology
  • Humans
 

Citation

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Leblond, V., Salehian, B. D., Borel, C., Mapakou, C. P., Dombret, H., Sutton, L., … Ankri, A. (1993). Alterations in natural anticoagulant levels during allogeneic bone marrow transplantation: a prospective study in 27 patients. Bone Marrow Transplant, 11(4), 299–305.
Leblond, V., B. D. Salehian, C. Borel, C. P. Mapakou, H. Dombret, L. Sutton, J. L. Binet, and A. Ankri. “Alterations in natural anticoagulant levels during allogeneic bone marrow transplantation: a prospective study in 27 patients.Bone Marrow Transplant 11, no. 4 (April 1993): 299–305.
Leblond V, Salehian BD, Borel C, Mapakou CP, Dombret H, Sutton L, et al. Alterations in natural anticoagulant levels during allogeneic bone marrow transplantation: a prospective study in 27 patients. Bone Marrow Transplant. 1993 Apr;11(4):299–305.
Leblond, V., et al. “Alterations in natural anticoagulant levels during allogeneic bone marrow transplantation: a prospective study in 27 patients.Bone Marrow Transplant, vol. 11, no. 4, Apr. 1993, pp. 299–305.
Leblond V, Salehian BD, Borel C, Mapakou CP, Dombret H, Sutton L, Binet JL, Ankri A. Alterations in natural anticoagulant levels during allogeneic bone marrow transplantation: a prospective study in 27 patients. Bone Marrow Transplant. 1993 Apr;11(4):299–305.

Published In

Bone Marrow Transplant

ISSN

0268-3369

Publication Date

April 1993

Volume

11

Issue

4

Start / End Page

299 / 305

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Tissue Plasminogen Activator
  • Protein S
  • Protein C
  • Prospective Studies
  • Plasminogen
  • Middle Aged
  • Male
  • Immunology
  • Humans