Alterations in natural anticoagulant levels during allogeneic bone marrow transplantation: a prospective study in 27 patients.

Journal Article (Journal Article)

The natural anticoagulants (antithrombin III, protein C, protein S), plasminogen and tissue plasminogen activator antigen (t-PA ag), were measured in 27 consecutive patients following allogeneic BMT. Thrombosis and veno-occlusive disease were not seen in this study. Changes in the levels of these proteins occurred mainly during acute GVHD. There were 14 patients who had no acute GVHD (group I) and 13 patients who had acute GVHD (group II). No changes in antithrombin III (ATIII), protein C, protein S and t-PA levels were found in group II before the appearance of acute GVHD when compared with group I. However, we noted a significant rise in protein S (p = 0.01), antithrombin III (p = 0.001) and t-PA ag (p = 0.0004) levels during acute GVHD. In contrast, protein C levels decreased early in GVHD (p = 0.005), and then increased progressively over the course of a month post-GVHD. No changes in plasminogen levels were observed. These results might reflect activation of and/or damage to endothelial cells during GVHD.

Full Text

Duke Authors

Cited Authors

  • Leblond, V; Salehian, BD; Borel, C; Mapakou, CP; Dombret, H; Sutton, L; Binet, JL; Ankri, A

Published Date

  • April 1993

Published In

Volume / Issue

  • 11 / 4

Start / End Page

  • 299 - 305

PubMed ID

  • 8485478

International Standard Serial Number (ISSN)

  • 0268-3369


  • eng

Conference Location

  • England