The SATE pronucleotide approach applied to acyclovir: part II. Effects of bis(SATE)phosphotriester derivatives of acyclovir on duck hepatitis B virus replication in vitro and in vivo.

Published

Journal Article

The in vitro and in vivo antiviral activities of two mononucleoside phosphotriester derivatives of acyclovir (ACV) incorporating S-acyl-2-thioethyl (SATE) groups are reported using the duck model of hepatitis B (DHBV). In primary duck hepatocyte cultures, the described phosphotriesters significantly inhibited the replication of DHBV at submicromolar concentrations. They were found to be more potent than the parent nucleoside. This result was in agreement with our data concerning the anti-HBV activity of these pronucleotides in HepG2.2.15 cells (previous paper). In vivo, the studied SATE pronucleotide was also found to be more efficient than ACV in infected ducklings upon short-term oral therapy, while intraperitoneal treatment showed high anti-DHBV activity with both ACV and its SATE pronucleotide in this animal model. These findings demonstrate the potential of SATE pronucleotides of ACV as anti-HBV agents.

Full Text

Duke Authors

Cited Authors

  • Hantz, O; Périgaud, C; Borel, C; Jamard, C; Zoulim, F; Trépo, C; Imbach, JL; Gosselin, G

Published Date

  • January 1999

Published In

Volume / Issue

  • 40 / 3

Start / End Page

  • 179 - 187

PubMed ID

  • 10027652

Pubmed Central ID

  • 10027652

International Standard Serial Number (ISSN)

  • 0166-3542

Digital Object Identifier (DOI)

  • 10.1016/s0166-3542(98)00060-6

Language

  • eng

Conference Location

  • Netherlands