Getting to the heart of regeneration in zebrafish.

Journal Article (Journal Article;Review)

A scientific and clinical prerogative of the 21st century is to stimulate the regenerative ability of the human heart. While the mammalian heart shows little or no natural regeneration in response to injury, certain non-mammalian vertebrates possess an elevated capacity for cardiac regeneration. Adult zebrafish restore ventricular muscle removed by surgical resection, events that involve little or no scarring. Recent studies have begun to reveal cellular and molecular mechanisms of this regenerative process that have exciting implications for human cardiac biology and disease.

Full Text

Duke Authors

Cited Authors

  • Poss, KD

Published Date

  • February 2007

Published In

Volume / Issue

  • 18 / 1

Start / End Page

  • 36 - 45

PubMed ID

  • 17178459

International Standard Serial Number (ISSN)

  • 1084-9521

Digital Object Identifier (DOI)

  • 10.1016/j.semcdb.2006.11.009


  • eng

Conference Location

  • England