Radiation therapy in stage II and III rectal cancer.


Journal Article (Review)

Over the past 25 years, significant advances have been made in the management of patients with rectal cancer. Phase III studies have shown the efficacy of postoperative radiation therapy and chemotherapy in improving local control and survival of patients with resected stage II and III disease. Data from the randomized German CAO/ARO/AIO-94 trial of preoperative versus postoperative chemoradiation have provided a strong rationale and support for the use of preoperative chemoradiation in the treatment of patients with clinical stage II and III rectal cancer. Current phase III studies are evaluating novel combinations of chemotherapy and targeted agents with radiation therapy.

Full Text

Duke Authors

Cited Authors

  • Willett, CG; Czito, BG; Bendell, JC

Published Date

  • November 15, 2007

Published In

Volume / Issue

  • 13 / 22 Pt 2

Start / End Page

  • 6903s - 6908s

PubMed ID

  • 18006798

Pubmed Central ID

  • 18006798

International Standard Serial Number (ISSN)

  • 1078-0432

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-07-1158


  • eng

Conference Location

  • United States