Multistage designs in the genomic era: providing balance in complex disease studies.

Journal Article (Journal Article;Review)

In this summary paper, we describe the contributions included in the Multistage Design group (Group 14) at the Genetic Analysis Workshop 15, which was held during November 12-14, 2006. Our group contrasted and compared different approaches to reducing complexity in a genetic study through implementation of staged designs. Most groups used the simulated dataset (problem 3), which provided ample opportunities for evaluating various staged designs. A wide range of multistage designs that targeted different aspects of complexity were explored. We categorized these approaches as reducing phenotypic complexity, model complexity, analytic complexity or genetic complexity. In general we learned that: (1) when staged designs are carefully planned and implemented, the power loss compared to a single-stage analysis can be minimized and study cost is greatly reduced; (2) a joint analysis of the results from each stage is generally more powerful than treating the second stage as a replication analysis.

Full Text

Duke Authors

Cited Authors

  • Dubé, M-P; Schmidt, S; Hauser, E; Darabi, H; Li, J; Barhdadi, A; Wang, X; Sha, Q; Zhang, Z; Wang, T; Aschard, H; Guedj, M; Rohlfs, R; Anderson, A; Taylor, C; Mirea, L; Nickolov, R; Milanov, V; Yang, H-C; Song, Y; Sinha, R

Published Date

  • 2007

Published In

Volume / Issue

  • 31 Suppl 1 /

Start / End Page

  • S118 - S123

PubMed ID

  • 18046769

Pubmed Central ID

  • PMC2582060

International Standard Serial Number (ISSN)

  • 0741-0395

Digital Object Identifier (DOI)

  • 10.1002/gepi.20288


  • eng

Conference Location

  • United States