A synthetic biology challenge: making cells compute.

Journal Article (Review;Journal Article)

Advances in biology and engineering have enabled the reprogramming of cells with well-defined functions, leading to the emergence of synthetic biology. Early successes in this nascent field suggest its potential to impact diverse areas. Here, we examine the feasibility of engineering circuits for cell-based computation. We illustrate the basic concepts by describing the mapping of several computational problems to engineered gene circuits. Revolving around these examples and past studies, we discuss technologies and computational methods available to design, test, and optimize gene circuits. We conclude with discussion of challenges involved in a typical design cycle, as well as those specific to cellular computation.

Full Text

Duke Authors

Cited Authors

  • Tan, C; Song, H; Niemi, J; You, L

Published Date

  • May 2007

Published In

Volume / Issue

  • 3 / 5

Start / End Page

  • 343 - 353

PubMed ID

  • 17460793

Electronic International Standard Serial Number (EISSN)

  • 1742-2051

International Standard Serial Number (ISSN)

  • 1742-206X

Digital Object Identifier (DOI)

  • 10.1039/b618473c


  • eng