Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart.

Published

Journal Article

The arterial pole of the heart is the region where the ventricular myocardium continues as the vascular smooth muscle tunics of the aorta and pulmonary trunk. It has been shown that the arterial pole myocardium derives from the secondary heart field and the smooth muscle tunic of the aorta and pulmonary trunk derives from neural crest. However, this neural crest-derived smooth muscle does not extend to the arterial pole myocardium leaving a region at the base of the aorta and pulmonary trunk that is invested by vascular smooth muscle of unknown origin. Using tissue marking and vascular smooth muscle markers, we show that the secondary heart field, in addition to providing myocardium to the cardiac outflow tract, also generates prospective smooth muscle that forms the proximal walls of the aorta and pulmonary trunk. As a result, there are two seams in the arterial pole: first, the myocardial junction with secondary heart field-derived smooth muscle; second, the secondary heart field-derived smooth muscle with the neural crest-derived smooth muscle. Both of these seams are points where aortic dissection frequently occurs in Marfan's and other syndromes.

Full Text

Duke Authors

Cited Authors

  • Waldo, KL; Hutson, MR; Ward, CC; Zdanowicz, M; Stadt, HA; Kumiski, D; Abu-Issa, R; Kirby, ML

Published Date

  • May 2005

Published In

Volume / Issue

  • 281 / 1

Start / End Page

  • 78 - 90

PubMed ID

  • 15848390

Pubmed Central ID

  • 15848390

Electronic International Standard Serial Number (EISSN)

  • 1095-564X

International Standard Serial Number (ISSN)

  • 0012-1606

Digital Object Identifier (DOI)

  • 10.1016/j.ydbio.2005.02.012

Language

  • eng