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Pegfilgrastim: a granulocyte colony-stimulating factor with sustained duration of action.

Publication ,  Journal Article
Lyman, GH
Published in: Expert Opin Biol Ther
December 2005

Granulocyte colony-stimulating factors such as filgrastim (Neupogen, Amgen, Inc.) and pegfilgrastim (Neulasta, Amgen, Inc.) are frequently used in clinical practice for the prevention of chemotherapy-induced neutropenia and its potentially life-threatening complications. Due to its unique neutrophil-mediated clearance, pegfilgrastim can be administered once per chemotherapy cycle. Clinical trials have shown that a single, fixed subcutaneous dose of pegfilgrastim 6 mg is comparable in safety and efficacy to daily injections of filgrastim for decreasing the incidence of infection following myelosuppressive chemotherapy in patients with cancer. Postregistrational trials have been conducted to evaluate the use of pegfilgrastim with emerging dose-dense regimens, in myeloid cancers and for mobilisation and engraftment of autologous stem cells. Ongoing clinical trials continue to explore further potential uses for pegfilgrastim.

Duke Scholars

Published In

Expert Opin Biol Ther

DOI

EISSN

1744-7682

Publication Date

December 2005

Volume

5

Issue

12

Start / End Page

1635 / 1646

Location

England

Related Subject Headings

  • Recombinant Proteins
  • Randomized Controlled Trials as Topic
  • Polyethylene Glycols
  • Neutropenia
  • Immunology
  • Humans
  • Granulocyte Colony-Stimulating Factor
  • Filgrastim
  • Delayed-Action Preparations
  • Animals
 

Citation

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Lyman, G. H. (2005). Pegfilgrastim: a granulocyte colony-stimulating factor with sustained duration of action. Expert Opin Biol Ther, 5(12), 1635–1646. https://doi.org/10.1517/14712598.5.12.1635
Lyman, Gary H. “Pegfilgrastim: a granulocyte colony-stimulating factor with sustained duration of action.Expert Opin Biol Ther 5, no. 12 (December 2005): 1635–46. https://doi.org/10.1517/14712598.5.12.1635.
Lyman, Gary H. “Pegfilgrastim: a granulocyte colony-stimulating factor with sustained duration of action.Expert Opin Biol Ther, vol. 5, no. 12, Dec. 2005, pp. 1635–46. Pubmed, doi:10.1517/14712598.5.12.1635.
Lyman GH. Pegfilgrastim: a granulocyte colony-stimulating factor with sustained duration of action. Expert Opin Biol Ther. 2005 Dec;5(12):1635–1646.

Published In

Expert Opin Biol Ther

DOI

EISSN

1744-7682

Publication Date

December 2005

Volume

5

Issue

12

Start / End Page

1635 / 1646

Location

England

Related Subject Headings

  • Recombinant Proteins
  • Randomized Controlled Trials as Topic
  • Polyethylene Glycols
  • Neutropenia
  • Immunology
  • Humans
  • Granulocyte Colony-Stimulating Factor
  • Filgrastim
  • Delayed-Action Preparations
  • Animals