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High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myeloma.

Publication ,  Journal Article
Ballester, OF; Moscinski, LC; Lyman, GH; Chaney, JV; Saba, HI; Spiers, AS; Klein, C
Published in: Blood
April 1, 1994

Interleukin-6 (IL-6) is a multifunctional cytokine postulated to play a central role as a growth factor for multiple myeloma (MM). We evaluated the spontaneous secretion of IL-6 in supernatants of Ficoll-Hypaque--enriched bone marrow (BM) cultures from 35 patients with MM. The levels of IL-6 were correlated with biological and clinical characteristics of the disease. High levels of IL-6 production defined a subgroup of patients with low tumor burden as determined by lower serum beta 2-microglobulin (B2M) (P = .02) and lower percentage of myeloma cells infiltrating the bone marrow (P = .003), higher synthetic rates of monoclonal protein (P = .006), and low proliferative compartments as measured by the percentage of Ki-67--positive myeloma cells. Patients with high proliferative fractions (Ki-67--positive myeloma cells > 20%) had significantly lower levels of IL-6 when compared with patients with low proliferative fractions (P = .005). Our findings do not support IL-6 as a major growth factor for MM, but demonstrate an association of high levels of IL-6 secretion with low tumor cell burden and low proliferative fraction.

Duke Scholars

Published In

Blood

ISSN

0006-4971

Publication Date

April 1, 1994

Volume

83

Issue

7

Start / End Page

1903 / 1908

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Survival Rate
  • Multiple Myeloma
  • Middle Aged
  • Male
  • Interleukin-6
  • Immunology
  • Humans
  • Female
  • Cell Division
 

Citation

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MLA
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Ballester, O. F., Moscinski, L. C., Lyman, G. H., Chaney, J. V., Saba, H. I., Spiers, A. S., & Klein, C. (1994). High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myeloma. Blood, 83(7), 1903–1908.
Ballester, O. F., L. C. Moscinski, G. H. Lyman, J. V. Chaney, H. I. Saba, A. S. Spiers, and C. Klein. “High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myeloma.Blood 83, no. 7 (April 1, 1994): 1903–8.
Ballester OF, Moscinski LC, Lyman GH, Chaney JV, Saba HI, Spiers AS, et al. High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myeloma. Blood. 1994 Apr 1;83(7):1903–8.
Ballester, O. F., et al. “High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myeloma.Blood, vol. 83, no. 7, Apr. 1994, pp. 1903–08.
Ballester OF, Moscinski LC, Lyman GH, Chaney JV, Saba HI, Spiers AS, Klein C. High levels of interleukin-6 are associated with low tumor burden and low growth fraction in multiple myeloma. Blood. 1994 Apr 1;83(7):1903–1908.

Published In

Blood

ISSN

0006-4971

Publication Date

April 1, 1994

Volume

83

Issue

7

Start / End Page

1903 / 1908

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Survival Rate
  • Multiple Myeloma
  • Middle Aged
  • Male
  • Interleukin-6
  • Immunology
  • Humans
  • Female
  • Cell Division