Membrane action of DMSO and other chemical inducers of Friend leukaemic cell differentiation.

Journal Article (Journal Article)

DMSO and other cryoprotective agents produce a pronounced increase on the phase transition temperature of phospholipid membranes, indicating an increased stability. The effects of DMSO and other cryoprotective agents, divalent cations, and local anaesthetics on the transition temperature of phospholipid membranes seem to correlate with their effects on the differentiation of Friend leukaemic cells in vitro. These studies suggest that the induction of differentiation by cryoprotective agents may be the result of the interaction of these agents with cell membranes.

Full Text

Duke Authors

Cited Authors

  • Lyman, GH; Preisler, HD; Papahadjopoulos, D

Published Date

  • July 29, 1976

Published In

Volume / Issue

  • 262 / 5567

Start / End Page

  • 361 - 363

PubMed ID

  • 986559

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/262360a0


  • eng

Conference Location

  • England