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Social and racial differences in selection of breast cancer adjuvant chemotherapy regimens.

Publication ,  Journal Article
Griggs, JJ; Culakova, E; Sorbero, MES; Poniewierski, MS; Wolff, DA; Crawford, J; Dale, DC; Lyman, GH
Published in: J Clin Oncol
June 20, 2007

PURPOSE: Breast cancer outcomes are worse among black women and women of lower socioeconomic status. The purpose of this study was to investigate racial and social differences in selection of breast cancer adjuvant chemotherapy regimens. METHODS: Detailed information on patient, disease, and treatment factors was collected prospectively on 957 patients who were receiving breast cancer adjuvant chemotherapy in 101 oncology practices throughout the United States. Adjuvant chemotherapy regimens included in any of several published guidelines were considered standard. Receipt of nonstandard regimens was examined according to clinical and nonclinical factors. Differences between groups were assessed using chi2 tests. Multivariate logistic regression was used to identify factors associated with use of nonstandard regimens. RESULTS: Black race (P = .008), lower educational attainment (P = .003), age 70 years (P = .001), higher stage (P < .0001), insurance type (P = .048), employment status (P = .045), employment type (P = .025), and geographic location (P = .021) were associated with the use of nonstandard regimens in univariate analyses. In multivariate analysis, black race (P = .020), lower educational attainment (P = .024), age > or = 70 years (P = .032), and higher stage (P < .0001) were associated with receipt of nonstandard regimens. CONCLUSION: The more frequent use of non-guideline-concordant adjuvant chemotherapy regimens in black women and women with lower educational attainment may contribute to less favorable outcomes in these populations. Addressing such differences in care may improve cancer outcomes in vulnerable populations.

Duke Scholars

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

June 20, 2007

Volume

25

Issue

18

Start / End Page

2522 / 2527

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Risk Factors
  • Prospective Studies
  • Patient Selection
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Logistic Models
  • Insurance, Health
 

Citation

APA
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Griggs, J. J., Culakova, E., Sorbero, M. E. S., Poniewierski, M. S., Wolff, D. A., Crawford, J., … Lyman, G. H. (2007). Social and racial differences in selection of breast cancer adjuvant chemotherapy regimens. J Clin Oncol, 25(18), 2522–2527. https://doi.org/10.1200/JCO.2006.10.2749
Griggs, Jennifer J., Eva Culakova, Melony E. S. Sorbero, Marek S. Poniewierski, Debra A. Wolff, Jeffrey Crawford, David C. Dale, and Gary H. Lyman. “Social and racial differences in selection of breast cancer adjuvant chemotherapy regimens.J Clin Oncol 25, no. 18 (June 20, 2007): 2522–27. https://doi.org/10.1200/JCO.2006.10.2749.
Griggs JJ, Culakova E, Sorbero MES, Poniewierski MS, Wolff DA, Crawford J, et al. Social and racial differences in selection of breast cancer adjuvant chemotherapy regimens. J Clin Oncol. 2007 Jun 20;25(18):2522–7.
Griggs, Jennifer J., et al. “Social and racial differences in selection of breast cancer adjuvant chemotherapy regimens.J Clin Oncol, vol. 25, no. 18, June 2007, pp. 2522–27. Pubmed, doi:10.1200/JCO.2006.10.2749.
Griggs JJ, Culakova E, Sorbero MES, Poniewierski MS, Wolff DA, Crawford J, Dale DC, Lyman GH. Social and racial differences in selection of breast cancer adjuvant chemotherapy regimens. J Clin Oncol. 2007 Jun 20;25(18):2522–2527.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

June 20, 2007

Volume

25

Issue

18

Start / End Page

2522 / 2527

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Risk Factors
  • Prospective Studies
  • Patient Selection
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Logistic Models
  • Insurance, Health