Double-blind placebo-controlled trial of oral cromolyn in children with atopic dermatitis and documented food hypersensitivity.


Journal Article

Ten children with challenge-proven egg hypersensitivity and atopic dermatitis were enrolled in a double-blind crossover trial of oral cromolyn sodium. After receiving up to 40 mg/kg/day of cromolyn or placebo for 1 week, patients underwent double-blind placebo-controlled oral food challenges. In the eight subjects who reacted to the food challenge, there was no significant difference in the amount of food allergen eliciting the positive response, the timing of onset until first subjective or objective symptoms developed, symptoms provoked, or the duration of the symptoms in either phase of the study. This study demonstrates no benefit in the treatment of children with atopic dermatitis and food hypersensitivity with oral cromolyn sodium.

Full Text

Cited Authors

  • Burks, AW; Sampson, HA

Published Date

  • February 1, 1988

Published In

Volume / Issue

  • 81 / 2

Start / End Page

  • 417 - 423

PubMed ID

  • 3123539

Pubmed Central ID

  • 3123539

Electronic International Standard Serial Number (EISSN)

  • 1097-6825

International Standard Serial Number (ISSN)

  • 0091-6749

Digital Object Identifier (DOI)

  • 10.1016/0091-6749(88)90910-4


  • eng