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Partial splenectomy for children with congenital hemolytic anemia and massive splenomegaly.

Publication ,  Journal Article
Diesen, DL; Zimmerman, SA; Thornburg, CD; Ware, RE; Skinner, M; Oldham, KT; Rice, HE
Published in: J Pediatr Surg
March 2008

Partial splenectomy is an alternative to total splenectomy for the treatment of congenital hemolytic anemias (CHAs) in children, although the feasibility of this technique in the setting of massive splenomegaly is unknown. This study was designed to evaluate the safety and efficacy of partial splenectomy in children with CHAs and massive splenomegaly. This retrospective study examined 29 children with CHAs who underwent partial splenectomy. Children were divided into 2 groups based on splenic size: 8 children had splenic volumes greater than 500 mL, whereas 21 children had splenic volumes less than 500 mL. Outcome variables included perioperative complications, transfusion requirements, hematocrits, reticulocyte counts, bilirubin levels, splenic sequestration, and splenic regrowth. All 29 children underwent successful partial splenectomy with 0.02 to 10 years of follow-up. After partial splenectomy, children overall had decreased transfusion requirements, increased hematocrits, decreased bilirubin levels, decreased reticulocyte counts, and elimination of splenic sequestration. Children with massive splenomegaly had similar outcomes compared with children without massive splenomegaly. Long-term complications included 3 mild infections, 4 cases of gallstones requiring cholecystectomy, and 1 child who required completion splenectomy. Partial splenectomy is a safe, effective, and technically feasible option for children with various CHAs, even in the setting of massive splenomegaly.

Duke Scholars

Published In

J Pediatr Surg

DOI

EISSN

1531-5037

Publication Date

March 2008

Volume

43

Issue

3

Start / End Page

466 / 472

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Splenomegaly
  • Splenectomy
  • Severity of Illness Index
  • Risk Assessment
  • Retrospective Studies
  • Pediatrics
  • Male
  • Humans
  • Follow-Up Studies
 

Citation

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ICMJE
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Diesen, D. L., Zimmerman, S. A., Thornburg, C. D., Ware, R. E., Skinner, M., Oldham, K. T., & Rice, H. E. (2008). Partial splenectomy for children with congenital hemolytic anemia and massive splenomegaly. J Pediatr Surg, 43(3), 466–472. https://doi.org/10.1016/j.jpedsurg.2007.10.025
Diesen, Diana L., Sherri A. Zimmerman, Courtney D. Thornburg, Russell E. Ware, Michael Skinner, Keith T. Oldham, and Henry E. Rice. “Partial splenectomy for children with congenital hemolytic anemia and massive splenomegaly.J Pediatr Surg 43, no. 3 (March 2008): 466–72. https://doi.org/10.1016/j.jpedsurg.2007.10.025.
Diesen DL, Zimmerman SA, Thornburg CD, Ware RE, Skinner M, Oldham KT, et al. Partial splenectomy for children with congenital hemolytic anemia and massive splenomegaly. J Pediatr Surg. 2008 Mar;43(3):466–72.
Diesen, Diana L., et al. “Partial splenectomy for children with congenital hemolytic anemia and massive splenomegaly.J Pediatr Surg, vol. 43, no. 3, Mar. 2008, pp. 466–72. Pubmed, doi:10.1016/j.jpedsurg.2007.10.025.
Diesen DL, Zimmerman SA, Thornburg CD, Ware RE, Skinner M, Oldham KT, Rice HE. Partial splenectomy for children with congenital hemolytic anemia and massive splenomegaly. J Pediatr Surg. 2008 Mar;43(3):466–472.
Journal cover image

Published In

J Pediatr Surg

DOI

EISSN

1531-5037

Publication Date

March 2008

Volume

43

Issue

3

Start / End Page

466 / 472

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Splenomegaly
  • Splenectomy
  • Severity of Illness Index
  • Risk Assessment
  • Retrospective Studies
  • Pediatrics
  • Male
  • Humans
  • Follow-Up Studies