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Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma.

Publication ,  Journal Article
McLaughlin, PW; Mancini, WR; Stetson, PL; Greenberg, HS; Nguyen, N; Seabury, H; Heidorn, DB; Lawrence, TS
Published in: Int J Radiat Oncol Biol Phys
July 15, 1993

PURPOSE: To determine the potential advantage of combining halogenated pyrimidine radiosensitization and continuous low dose rate irradiation in human malignant glioma. METHODS AND MATERIALS: An established glioma line (U-251) was incubated with 5-bromo-2-doxyuridine (BrdUrd) at clinically achievable concentrations at three dose rates of interest--100 cGy/min (typical of external beam therapy), 43 cGy/hr (typical of temporary afterloaded implants), and 12 cGy/hr (typical of permanent implants). RESULTS: After exposure to 1 microM BrdUrd, the greatest enhancement ratio was seen at the 12 cGy/hr dose rate, implying a BrdUrd induced inverse dose rate effect independent of a G2M block. Under these conditions, the mean inactivation dose after 1 microM BrdUrd exposure was equivalent for 100 cGy/min and 12 cGy/hr. CONCLUSION: These results support the use of halopyrimidines as sensitizers of temporary afterloaded and permanent implants.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

July 15, 1993

Volume

26

Issue

4

Start / End Page

637 / 642

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Survival Rate
  • Radiotherapy Dosage
  • Radiation-Sensitizing Agents
  • Oncology & Carcinogenesis
  • In Vitro Techniques
  • Humans
  • Glioma
  • Dose-Response Relationship, Radiation
  • Bromodeoxyuridine
 

Citation

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MLA
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McLaughlin, P. W., Mancini, W. R., Stetson, P. L., Greenberg, H. S., Nguyen, N., Seabury, H., … Lawrence, T. S. (1993). Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma. Int J Radiat Oncol Biol Phys, 26(4), 637–642. https://doi.org/10.1016/0360-3016(93)90281-y
McLaughlin, P. W., W. R. Mancini, P. L. Stetson, H. S. Greenberg, N. Nguyen, H. Seabury, D. B. Heidorn, and T. S. Lawrence. “Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma.Int J Radiat Oncol Biol Phys 26, no. 4 (July 15, 1993): 637–42. https://doi.org/10.1016/0360-3016(93)90281-y.
McLaughlin PW, Mancini WR, Stetson PL, Greenberg HS, Nguyen N, Seabury H, et al. Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma. Int J Radiat Oncol Biol Phys. 1993 Jul 15;26(4):637–42.
McLaughlin, P. W., et al. “Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma.Int J Radiat Oncol Biol Phys, vol. 26, no. 4, July 1993, pp. 637–42. Pubmed, doi:10.1016/0360-3016(93)90281-y.
McLaughlin PW, Mancini WR, Stetson PL, Greenberg HS, Nguyen N, Seabury H, Heidorn DB, Lawrence TS. Halogenated pyrimidine sensitization of low dose rate irradiation in human malignant glioma. Int J Radiat Oncol Biol Phys. 1993 Jul 15;26(4):637–642.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

July 15, 1993

Volume

26

Issue

4

Start / End Page

637 / 642

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Survival Rate
  • Radiotherapy Dosage
  • Radiation-Sensitizing Agents
  • Oncology & Carcinogenesis
  • In Vitro Techniques
  • Humans
  • Glioma
  • Dose-Response Relationship, Radiation
  • Bromodeoxyuridine