The effect of medroxyprogesterone acetate on blood pressure.


Journal Article

Twenty-four women (21 normotensive and 3 hypertensive) aged 16-35 years received 150-mg injections of medroxyprogesterone acetate (MPA) for contraception. Their blood pressure (BP) was measured under basal conditions by the same nurse before treatment and at 1-, 2- and 3-month intervals. Their mean BP fell from 124.1/79.4 to 119.8/74.6 mm Hg at one month (p less than 0.05 for diastolic pressure) to 117.0/74.9 mm Hg at two months and to 115.6/73.2 mm Hg at three months. When the normotensive patients were analyzed separately, their BP fell, but not significantly. Only one patient had a rise of 20 mm Hg systolic, but she remained normotensive. We conclude that medroxyprogesterone acetate does not raise BP.

Full Text

Duke Authors

Cited Authors

  • Black, HR; Leppert, P; DeCherney, A

Published Date

  • July 1, 1978

Published In

Volume / Issue

  • 17 / 1

Start / End Page

  • 83 - 87

PubMed ID

  • 39845

Pubmed Central ID

  • 39845

International Standard Serial Number (ISSN)

  • 0020-7292

Digital Object Identifier (DOI)

  • 10.1002/j.1879-3479.1979.tb00121.x


  • eng

Conference Location

  • United States